Scientific Advisor - ADME Project Leadership Biologics

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.

Our diverse ADME team is seeking a dedicated and enthusiastic scientist interested in the discovery and clinical development of medicines across multiple modalities, with a particular emphasis on biologics and drug conjugates. If you have a talent for finding creative solutions to complex problems, apply today! We want you on our team.

Our scientifically agile team works collaboratively with biologists, chemists, engineers and various other R&D functions to deliver novel therapies to patients. We support one another through shared-learning and mutual-responsibility for the enterprise of making medicines. Ours is a flexible environment where each team member can optimize their productivity while being mindful of wellness. This enables each of us to grow our careers as well as the scientific field in our search for safe and effective medicines.

Please connect with us if you are a motivated and collaborative scientist looking for an opportunity to innovate at the forefront of novel therapies to improve the lives of patients.

• High learning agility and a keen ability to derive and efficiently test ADME and DMPK hypotheses for novel molecules with particular emphasis on antibodies
• Strong working knowledge in fundamental pharmaceutics, pharmacokinetics and ADME principles especially as they relate to biologics such as antibodies and conjugated molecules
• Understanding of contemporary pharmaceutical regulatory guidance and expectations
• Skills to integrate internal and external laboratory and other experimental resources through high quality scientific associations
• Agile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and performance characteristics

• Lead and innovate in a multidisciplinary collaborative environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly portfolio
• Design and implement hypothesis driven studies to answer ADME, PK/PD and clinical pharmacology questions
• Integrate ADME, PK and PK/PD endpoints with discovery biology data to define structure activity- and structure-property-relationships to guide drug delivery and optimization strategies
• Engage, innovate, and collaborate with colleagues and interdisciplinary teams
• Lead the preparation of regulatory communication and documents to support clinical development, new drug applications (NDA and BLA) and line extensions and interact with regulatory agencies worldwide
• Build and foster relationships through coaching and mentorship with fellow scientists
• Possess excellent written and verbal technical communication skills and the ability to lead, guide and influence teams in decision making

Onsite presence (minimum of 3 days/week) at either our headquarters in Indianapolis, Indiana, or our Harborside location in Boston, Massachusetts

Ph.D. in Biology, Cellular or Molecular Biology, Biochemistry, Pharmaceutical Sciences, Pharmacokinetics or a related scientific field; experience in the discovery and development of biological-therapeutics highly preferred

• Industry (Pharma/Biotech) experience (1- 7 years) in the preclinical evaluation of biologics and or hybrid modalities, as well as relevant ADME project leadership experience
• Understanding of and experience with immunoassays, and/or LC/MS bioanalytical methodology
• Detailed understanding of pharmacokinetics, ADME and proficiency to communicate theory and concepts clearly
• Experience in drug discovery and development
• Experience with PK/PD modeling and/or bio-distribution
• Ability to balance multiple projects and handle competing responsibilities
• Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community
• Excellent oral and written communication skills
• Experience authoring regulatory and technical reports

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form  for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not…