Senior Advisor – Discovery ADMET; ADME, Toxicology Project Leader

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.

Lilly is a global healthcare leader headquartered in Indianapolis, Indiana. Our 50,000 employees around the world work to discover and bring life-changing medicines to those who need them. At Lilly, the Discovery Investigative ADME, Toxicology and Bio Analytical Research team focuses on pre-clinical discovery using innovative science and technology approaches to treat diseases with poor treatment options.

We are seeking a n experienced, accomplished drug hunter as a Discovery ADME Project Leader. The ideal candidate will provide deep mechanistic understanding of drug disposition, PK, and translational science, plus the ability to integrate biology, chemistry, and modeling. Experience with Small Molecule Discovery and in project teams with Beyond-Rule-of-Five and pan-modality chemo-types is advantageous. The successful candidate will bring outstanding scientific depth and acumen as an integral member of the project team to build ambitious Target Product Profiles, help establish design strategy and expectations, partner globally and cross-functionally and ensure teams are advancing The Right Molecule to The Right Study at The Right Time (our three R’s).

Geography for this position is open to Indianapolis IN, Louisville CO or Boston MA.

• Keep Safety as a priority.
• Develop and implement integrated preclinical ADME T strategies aligned with discovery stage, target product profile (TPP), design hypotheses being tested, and regulatory expectations.
• As the ADME T Project Leader, bring integrated Toxicology subject matter expertise, driving integrated ADMET strategy by aligning pharmacokinetics, metabolism, and mechanistic disposition data with early safety signals; interpret exposure–toxicity relationships, therapeutic index, and off-target liabilities to proactively de-risk programs and enable data-driven candidate selection decisions.
• Integrate ADME, pharmacology, and toxicology to enable translational simulations and modeling to support dose selection, design of PK/PD, efficacy and safety studies.
• Define stage-, modality-, and issue-appropriate screening, decision funnels (in silico, in vitro, in vivo to translational modeling).
• Guide compound design and optimization through data-driven design principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
• Serve as the ADME T strategy and science single-point-of-accountability on cross-functional program teams, translating ADME T findings into actionable design and test hypotheses.
• Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery Functions to drive high quality candidate selection; contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
• Represent ADME T in portfolio governance discussions and leadership reviews.
• Implement standards, assay innovation, and automation where appropriate; drive innovation in data reporting, knowledge management, and decision frameworks; seek and leverage AI and agentic tools where possible to pipeline data, interpret data and share results.
• Maintain inspection-ready documentation and alignment with regulatory expectations.
• Mentor, guide and grow junior scientists and contribute to functional capability building.

• PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical or Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or scientific field.
• 3+ years of post-graduation industry…