Biologist – Neurodegeneration, Histology​/Imaging

Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and strive to make life better for people around the world.

Eli Lilly and Company seeks a highly motivated scientist to join our Neurodegeneration team. This position is part of a multidisciplinary team dedicated to discovering novel medicines for the treatment of Alzheimer’s disease, Parkinson’s disease, ALS, and other related neurodegenerative conditions. The individual will apply histological and imaging techniques to support our expanding neurodegeneration portfolio. A primary focus is the establishment and use of imaging/histological techniques to support therapeutic investigations in multiple pre-clinical animal models.

• Perform histological techniques including tissue processing, paraffin embedding, tissue sectioning, routine and special tissue staining, imaging and image analysis.
• Establish and execute multiplexed immunohistochemistry (IHC) and in situ hybridization (RNAScope) to evaluate in vivo efficacy of therapeutic agents.
• Contribute to development, validation, and performing advanced histological/imaging techniques such as spatial transcriptomics, super-resolution microscopy, light sheet microscopy and in vivo two-photon imaging.
• Assist in troubleshooting technical challenges and provide scientific/technical input to project teams.
• Design, execute experiments and perform data analysis.
• Communicate results to the project team to drive data-driven decisions.
• Provide written and verbal communication of work in lab reports and team meetings.
• Accurately record all practical work in an electronic notebook following Lilly procedure quality standards.
• General laboratory assistance, including ordering and receiving lab supplies, preparing reagents, and maintaining laboratory equipment.
• Ensure compliance with health and safety regulations.
• Report on-site, in the lab, 5 days a week.

• Bachelor’s degree in Neuroscience, Biological Sciences, or related field.
• Two years of academic or industry experience with histologic analysis of animal models.

• Previous experience in neuroscience research is preferred.
• Hands-on experience with autostainers (e.g., Leica Bond-RX) and slide scanner imaging (e.g., Olympus VS200).
• Knowledge of image analysis software such as HALO, QuPATH and Image
  
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• Experience in stereotactic surgery and in vivo imaging is a plus.
• Hands-on experience in cDNA library preparation for transcriptomics is a plus.
• Ability to design, execute and interpret experiments independently.
• Excellent communication and collaborative skills across functional teams.
• Strong organizational skills, attention to detail, critical thinking, multitasking, and willingness to learn new techniques in a fast-paced environment.

Lilly is committed to helping individuals with disabilities participate in the workforce and ensuring equal opportunity for jobs. If you require an accommodation to submit a resume, please email Lilly Human Resources for assistance. This email is intended for accommodation requests as part of the application process.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability, or any other legally protected status.

Lilly’s compensation and benefits programs may be amended at the company’s discretion. Actual compensation will depend on education, experience, skills, and location. Benefits include medical, dental, vision, life insurance, retirement plans, paid time off, and well-being programs. Compensation practices for promotions or transfers are at Lilly’s discretion.

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