Advisor​/Sr. Advisor - Downstream Purification Development

Location: Indianapolis

Advisor/Sr. Advisor - Downstream Purification Development page is loaded## Advisor/Sr. Advisor - Downstream Purification Development locations:
US, Indianapolis INtime type:
Full time posted on:
Posted Yesterday time left to apply:
End Date:
March 13, 2026 (1 day left to apply) job requisition :
R-96560

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.
** Overview:
** At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Bioproduct Research and Development (BRD) is the large-molecule process development organization within Lilly.  BRD is responsible for material and data generation to support clinical trials and commercialization of biologic therapeutics such as mAbs and bioconjugates. Our team works to accelerate the development and manufacturing of new bioconjugate medicines for our patients. We perform innovative and cutting-edge research to deliver bioconjugation processes, knowledge, and best practices to support clinical trials and commercialization for antibody-drug conjugates (ADCs), antibody-peptide conjugates (APCs), and antibody-RNA conjugates (ARCs/AOCs).  

We collaborate with our Synthetic Molecule Design and Development (SMDD), discovery, and biologics development colleagues to advance this exciting class of new drugs and seek fundamental learning and platform approaches to their development.
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* Position Summary:

** The scientist is responsible for collaborating with teams of scientists and engineers in the development and optimization of purification processes for the production of recombinant therapeutic proteins as well as for process control strategy development, process scale-up and technology transfer to pilot plant and manufacturing sites. The scientist is also responsible for leading/supporting organizational strategic initiatives, evaluating and/or installing new capabilities/technologies and leveraging internal and external influence to solve problems and benchmark potential solutions.
** Responsibilities:
*** Lead the design, execution, and interpretation of appropriate purification development experiments to drive the definition and optimization of downstream processes for the generation of recombinant protein active pharmaceutical ingredients.
* Use first principles and designed experiments (DOE) to predict/understand/control the impact of physical and chemical processing conditions on recombinant protein product quality.
* Lead the development of validated scaled-down models of key bioprocess unit operations including: filtration/TFF, chromatography operations and freeze/thaw.
* Participate in and/or lead cross-functional process development teams and effectively collaborate with other groups in Bioprocess and Bioproduct Development, Discovery, Technical services for Manufacturing and Manufacturing.
* Support transfer of purification processes to technical services for Manufacturing laboratories and pilot plant/manufacturing sites.
* Authorship of technical reports and regulatory documents.
* Work effectively with external parties on development projects, research collaborations and outsourcing efforts.
* Lead/support implementation of organizational strategic initiatives in support of the Lilly pipeline.
* Keep abreast of relevant scientific literature and new technologies/capabilities and regulatory initiatives/requirements. Lead implementation, as appropriate.
* Leverage internal…