Advisor ADC Drug-Linker Synthetic Process Development

Advisor ADC Drug-Linker Synthetic Process Development

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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life‑changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.

The Bioproduct Research and Development (BR&D) organization strives to deliver innovative medicines to patients through the development and commercialization of monoclonal antibodies, novel therapeutic proteins, peptides, bioconjugates, cell therapies, gene therapies, and other genetic medicines. This multidisciplinary group works collaboratively with discovery, manufacturing, quality, and business units.

This role focuses on small‑molecule drug‑linker synthetic chemistry within  &D. With a strategic commitment to Antibody‑Drug Conjugates (ADCs) and an exciting pipeline, we seek outstanding candidates to work at the small‑molecule–biologics interface. The successful candidate will interface closely with biologics development and the Synthetic Molecule Design and Development organization.

• Synthesize complex payloads and drug‑linkers for preclinical toxicology studies, collaborating across internal Lilly networks to implement and deliver material.
• Apply deep knowledge of synthetic organic chemistry methods, technologies, and techniques to design and develop robust synthetic manufacturing processes for clinical manufacturing campaigns.
• Apply solid understanding of unit operations, process modeling, equipment selection, and scale‑up methodologies.
• Work closely with early‑phase Discovery and Toxicology groups to support new and emerging assets in the portfolio via synthetic material supply.
• Provide technical leadership in scale‑up and demonstration of new chemical processes in development‑scale equipment, collaborating with internal and external manufacturing partners.
• Design experimental laboratory plans to support route and process design, definition, optimization, and technology transfer objectives.
• Support generation of data for regulatory filings and address key CMC regulatory questions that enable clinical studies.
• Engage the external chemistry community through presentations and publications.
• Collaborate with Lilly chemists, analytical chemists, bioconjugation scientists, engineers, CMC project management, manufacturing partners, and regulatory scientists to develop and commercialize ADCs.
• Oversee phase‑appropriate development activities such as route selection, process definition, and process characterization.
• Partner with external development and manufacturing organizations to deliver data and material quickly.
• Author technical reports and CMC related documents including sections in regulatory submission documents (e.g., IND, IMPD, BLA).
• Help drive internal facilities growth to support highly‑potent and/or cytotoxic material handling through laboratory design and planning.

• Ph.D. in synthetic organic chemistry or a relevant scientific discipline with 0‑2 years of industry experience, OR M.S. with 5+ years of relevant synthetic chemistry experience in an industry setting.

• Experience in a high‑potent laboratory environment handling high‑potent and/or cytotoxic compounds.
• Experience with Antibody‑Drug Conjugates (ADCs).
• Active scientific curiosity and interest in complementary disciplines within the pharmaceutical industry.
• Familiarity with preparative‑scale chromatographic purification of small molecules.

• Potential exposure to chemicals, allergens, and loud noises.
• Travel: 0–20%
• Full‑time salaried position.
• Location:
  
  Indianapolis, Indiana, Lilly Technology Center – North.

Mid‑Senior…