Scientist II, Biologics Drug Product Development

Job description:
The Biologics CMC Develop ability (BCD) group sits at the interface of discovery and development. The core role of BCD is to deliver meaningful and actionable data to support the selection of candidate molecules to progress through the pipeline into later stages of development. The group applies high-throughput (HT) assays and leverages automation to enable screening on a wide range of biologics.

We are currently undertaking a multi-year initiative to collect data on a diverse selection of molecules using these established HT screening assays and automation.
Responsibilities:

• Sample preparation, data collection, and data analysis on established HT screening assays.
• Method development and execution of Client HT assays.
• Maintain an electronic lab notebook in alignment with company documentation policies.
• Stay current with scientific literature and support new scientific initiatives.

• BS or MS in a scientific field and typically 4 (BS) or 2 (MS) years of relevant experience.
• Hands-on experience using analytical methods for chemical and structural characterization of biologics e.g. HPLC/UPLC, capillary electrophoresis, and other biophysical techniques (UV-vis, DLS, DSF, etc.) for protein characterization is a requirement.
• Scientific understanding of the structure & function of monoclonal antibodies, antibody constructs/conjugates, bispecific, and fusion proteins and their modes of degradation/stabilization.
• Strong laboratory skills focused on formulation development for monoclonal antibodies and antibody constructs/conjugates (standard excipient selection, functional excipients, high throughput assays).
• Desired:
  Experience with digital data capture tools and systems.

• 3-5 years of experience.
• Masters with 0 years of experience is ok.
• Okay to teach and guide them.
• Science background.
• Stand out if they have research lab experience, undergrad or master's research lab.
• Any type of wet lab skill.
• HPLC, Liquid handling major plus.
• PHD overqualified.