Senior Principal AI​/ML Scientist, Computational Imaging

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Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happily lives.

Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Principal AI/ML Scientist, Computational Imaging

Let’s do this. Let’s change the world. Biomarkers and diagnostics are central to understanding how our therapeutics work and identifying patients that benefit most from these therapies. Accordingly, the Precision Medicine (PMED) function plays a critical role in advancing our drug development programs and is accountable for the development and execution of biomarkers and diagnostics strategy across our pipeline. The PMED Center for Technology and Innovation group is responsible for developing innovative biomarker assay and computational technologies that advance precision medicine objectives across therapeutic areas.

We are currently seeking an AI/ML imaging expert to join our growing Computational Imaging and Digital Biomarkers team. The Senior Principal Scientist, Computational Imaging, will serve as a technical leader and hands‑on scientific contributor in the development and application of advanced AI/ML methods for medical imaging, with a focus on digital pathology and/or radiology. This role is responsible for leading complex imaging AI efforts and delivering high‑impact models that support biomarker discovery, patient stratification, disease characterization, and outcome prediction.

The successful candidate will bring deep expertise in custom AI model development, particularly in leveraging public and proprietary foundation models to develop novel segmentation, classification, and predictive models. This role operates in a matrixed environment, partnering closely with translational pathology, clinical imaging, clinical biomarkers, and computational biologist stakeholders, while mentoring junior scientists and influencing external collaborations. This position will report directly to the Executive Director of Computational Imaging and Digital Biomarkers.

In this vital role you will successfully partner with cross‑functional stakeholders to drive development and implementation of imaging‑based biomarkers and diagnostics.

• Lead the design, development, training, and validation of AI/ML models for digital pathology and/or radiology applications.
• Define technical direction for custom AI/ML model development, including architecture selection, training paradigms, validation strategies, and performance benchmarks.
• Develop custom deep learning architectures and workflows for segmentation, classification, representation learning, and prediction tasks.
• Leverage and adapt foundation models (e.g., vision transformers, multimodal and self‑supervised models), including fine‑tuning and domain adaptation using proprietary datasets.

• Extract insights from large‑scale imaging datasets, including whole‑slide images and radiology modalities (CT, MRI, PET).
• Apply advanced computer vision and machine learning methods, including CNNs, U‑Net variants, Vision Transformers, diffusion‑based or representation‑learning models.
• Define appropriate evaluation strategies and ensure analytical rigor, reproducibility, and scientific credibility.
• Integrate imaging data with clinical, molecular, or spatial‑omics data where relevant.
• Balance innovation with practicality, ensuring…