LCMS Chemist

Job Title:

LCMS Chemist Job Description

This part-time position requires 5‑10 hours of work per week, typically scheduled between 3pm to 6pm CT, depending on the availability of the LCMS instrument. As an LC‑MS Chemist, you will execute analytical methods via LC‑MS to support product development in a Pharmaceutical/Biotech environment.

• Run high‑throughput LC‑MS analyses to support medicinal chemistry screening, including hit identification and structure–activity relationship (SAR) cycles.
• Execute experiments to develop and validate small molecule drug development.
• Utilize specialized software for data processing and reporting, potentially including Mass Lynx, Xcalibur, ACD, and Metasite.
• Characterize raw materials, intermediates, and final products for identity, purity, potency, and stability.
• Collaborate with formulation scientists, process engineers, and quality teams to support product development.
• Report analytical data, ensuring scientific rigor and compliance to SOPs.
• Operate, clean, and maintain LC‑MS systems.
• Troubleshoot chromatographic and MS issues, such as ion suppression, poor peak shape, or sensitivity loss.

• Hands‑on experience operating and executing LC‑MS runs, with the ability to run and verify performance.
• Proficiency in sample preparation.
• Strong documentation and communication skills.
• Understanding of Mass Spectrometry theory and common procedures.
• 3–5 years of experience in an analytical chemistry laboratory environment.
• Degree in Chemistry, Analytical Chemistry, Pharmaceutical Sciences, or related field (Master’s or PhD preferred).
• Proficiency and hands‑on experience with LC‑MS systems.

• Data processing and interpretation, analyzing chromatograms, LC‑MS spectra, and quantitative results.
• Problem‑solving and troubleshooting skills for diagnosing chromatographic issues, ion‑source problems, contamination, or instrument drift.
• Preferred understanding of LC‑MS workflows in drug discovery/small‑molecule development.
• Preferred experience in method development and optimization.

This is a laboratory‑based role with exposure to chemicals and analytical instrumentation. The candidate must be able to wear appropriate personal protective equipment (PPE) and follow safety protocols. Manual dexterity and fine motor skills are required, as well as comfort with repetitive tasks. The environment is fast‑paced and iterative, with cross‑functional collaboration and data‑driven decision‑making. The role offers a flexible schedule and may require occasional lifting of lab supplies and extended periods of standing.

This is a Contract position based out of Houston, TX.

The pay range for this position is $45.00 - $50.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision

• Critical Illness, Accident, and Hospital

• 401(k) Retirement Plan – Pre‑tax and Roth post‑tax contributions available

• Life Insurance (Voluntary Life & AD&D for the employee and dependents)

• Short and long‑term disability

• Health Spending Account (HSA)

• Transportation benefits

• Employee Assistance Program

• Time Off/Leave (PTO, Vacation or Sick Leave)

This is a fully onsite position in Houston,TX.

This position is anticipated to close on Mar 20, 2026.

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email actalentaccom