Research & Development Scientist III, Algorithm Developer

SUMMARY

We are seeking an R&D Scientist in Algorithm Development to support the development, validation, and quality assurance of next generation sequencing (NGS) assays and analysis pipelines. This role involves performing in-depth analytical evaluation of NGS sequencing data to assess sequencing quality metrics, support assay development, and ensure robust downstream interpretation. The successful candidate will validate and verify computational algorithms used within NGS analysis pipelines, contribute to NGS panel design, support quality assurance efforts, and conduct end-to-end validation of NGS analysis pipelines to ensure analytical accuracy, reproducibility, and robustness.

This position requires thorough documentation of analytical methods, validation studies, and pipeline updates in technical reports, supporting both internal development and regulatory needs. The R&D Scientist will work collaboratively with cross functional teams, including assay development, bioinformatics, and quality groups.

Candidates should hold a Ph.D. in Bioinformatics, Computational Biology, Genomics, Computer Science, or a related field, or an M.S. with 3+ years of relevant experience. Required expertise includes hands‑on experience with NGS data analysis, particularly sequencing performance metrics, as well as strong programming skills in Python and/or R.

• Perform in-depth analytical analysis of NGS sequencing data to evaluate sequencing performance metrics and support assay development
• Validate and verify computational algorithms used within NGS analysis pipelines
• Support NGS panel design activities, including analytical assessment and quality considerations
• Conduct end-to-end validation of NGS analysis pipelines to ensure accuracy, reproducibility, and robustness
• Support quality assurance efforts through data review, troubleshooting, and performance monitoring
• Document analytical methods, validation studies, and pipeline updates in clear, well‑structured technical reports
• Collaborate with cross functional teams, including assay development, bioinformatics, and quality, to support R&D objectives

• Ph.D. in Bioinformatics, Computational Biology, Genomics, Computer Science, or a related field; or M.S. with 3+ years of relevant experience
• Hands‑on experience with NGS data analysis, including evaluation of sequencing performance metrics and assay quality
• Experience validating computational algorithms or bioinformatics analysis pipelines
• Proficiency in Python and/or R for data analysis and pipeline development
• Strong analytical, documentation, and collaboration skills within a cross‑functional R&D environment

• Knowledge of clinical genomics applications, including NIPT or cancer genomics
• Experience or familiarity with pharmacogenomics (PGx) and complex variant analysis
• Exposure to rare disease genomics and germline variant analysis

• Frequently required to sit
• Frequently required to stand
• Frequently required to utilize hand and finger dexterity
• Frequently required to talk or hear
• Frequently required to utilize visual acuity to operate equipment, read technical information, and/or use a keyboard.
• Occasionally exposed to blood borne and airborne pathogens or infectious materials

Baylor Genetics is proud to be an equal opportunity employer dedicated to building an inclusive and diverse workforce. We do not discriminate based on race, religion, color, national origin, sex, sexual orientation, age, gender identity, veteran status, disability, genetic information, pregnancy, childbirth, or related medical conditions, or any other status protected under applicable federal, state, or local law.

This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.