Postdoctoral Fellow - Infectious Disease & Infection Control-Research
Listed on 2026-02-28
-
Research/Development
Research Scientist, Clinical Research -
Healthcare
Clinical Research
Overview
A Postdoctoral Fellow position is available in the laboratory of Dr. David Tweardy in the Department of Infectious Diseases, Division of Internal Medicine at The University of Texas MD Anderson Cancer Center. The Tweardy Laboratory focuses on the discovery and pre-clinical development of small-molecule inhibitors and proteolysis targeting chimeras (PROTACs) that target disease-causing proteins, including STAT3 and RASH3D19, for the treatment of cancer and fibrosis.
TTI-101, a small molecule discovered by the group that selectively targets the STAT3 SH2 domain, is being tested in patients for treatment of liver cancer and idiopathic pulmonary fibrosis.
The efforts of this Postdoctoral Fellow will focus on identifying candidate small-molecules and peptides that block the binding of domains (D and
E) to the proline-rich region (PRR) of SOS2 using surface plasmon resonance. Promising candidates will advance to hit-to-lead efforts and be tested in mouse models of mutant RAS-driven cancers. All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.
Exercise imagination and initiative in planning and executing experiments to determine the specific contributions of SH3 domain D alone, domain E alone, and the combination of SH3 domains D and E to affinity of binding to SOS2 PRR; identify residue contributions within the SOS2 PRR that affect binding affinity; develop strategies for reducing affinity through identification of small peptides and small molecules that interfere with binding;
and design and develop PROTACS that cause degradation of RASH3D19.
Master and perform wet-lab techniques, particularly SPR (or similar technology), along with cDNA cloning and mutagenesis, bacterial protein expression and purification, SDS-PAGE, and immunoblotting.
Record and evaluate data meticulously; draft progress reports, abstracts, and manuscripts; and present findings at lab meetings and scientific conferences.
Collaborate with the Principal Investigator and senior staff to assist in the preparation of grant requests and reports.
Applications are invited from qualified individuals with a PhD or MD/PhD in biological sciences. The preferred candidate should have less than 2 years of prior postdoctoral experience.
Job Knowledge and
Skills:
- Scientific Background:
Strong background in protein chemistry, molecular biology and cellular biology is required. - Technical Expertise:
Experience in SPR (or similar technology), cDNA cloning and mutagenesis, bacterial protein expression and protein purification, SDS-PAGE, and immunoblotting is highly desired. - Animal
Experience:
Not required. - Professional and Emotional
Skills:
Rigorous and accurate experimental techniques; enthusiasm; high degree of self-motivation; ability to function independently and to work productively and collaboratively with other team members. Must possess command of the written and spoken English language and have a prior publication record.
MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000, depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition.
Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements.
This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.
#J-18808-Ljbffr(If this job is in fact in your jurisdiction, then you may be using a Proxy or VPN to access this site, and to progress further, you should change your connectivity to another mobile device or PC).