Sr. Scientist​/Principal Scientist - LC-MS​/MS

Seniority level:
Mid‑Senior level

Employment type:

Full‑time
Job function:
Science and Research
Industries:
Public Safety and Hospitals and Health Care

Department: R&D
Job Type: Regular Full Time
Location: Horsham, PA
Shift: 1st shift Monday through Friday

NMS Labs has developed an extensive menu of more than 2,500 tests to support clients in forensic, criminalistic, public health and clinical fields. For over 50 years, clients have relied on NMS Labs for unique testing solutions that demonstrate our core values of Quality, Integrity, Service, Innovation and Engagement. Visit

We are seeking an R&D scientist with deep expertise in LC‑MS/MS method development for the qualitative and quantitative analysis of small molecular drugs in biological samples (blood, serum, plasma, urine). The ideal candidate will demonstrate proficiency in using QQQ and/or QTOF instrument platforms and possess a proven track record of published methods, articles, abstracts, or patents. This role requires an independent thinker with leadership abilities to manage and drive projects effectively.

• Master’s degree or Ph.D. in Analytical Chemistry, Biochemistry, or a related field.
• Minimum 22 semester credit hours in college‑level chemistry coursework, including General Chemistry with labs, Organic Chemistry with labs, and 2 additional courses in Analytical Chemistry, Instrumental Analysis, Quantitative Analysis, or Physical Chemistry.
• Minimum 5 years of experience in LC‑MS/MS method development for the qualitative and quantitative analysis of biological samples (blood, serum, plasma, urine).
• Proficiency with QQQ and/or QTOF instrument platforms, preferably Sciex and Waters instruments.
• Established publication record, including methods, articles, abstracts, or patents.
• Demonstrated ability to work independently and lead projects and teams.
• Excellent problem‑solving, organizational, and communication skills.

• Design, develop, and validate LC‑MS/MS methods for small‑molecule analysis in complex biological matrices.
• Lead and/or manage projects, ensuring timely delivery of high‑quality results.
• Mentor junior team members, fostering a collaborative and productive work environment.
• Maintain and troubleshoot LC‑MS/MS instrumentation to ensure optimal performance.
• Evaluate and implement new technologies to enhance analytical capabilities.
• Prepare and publish scientific methods, articles, abstracts, or patents to contribute to the field.
• Collaborate with cross‑functional teams to support research and development initiatives.
• Ensure compliance with regulatory standards and laboratory best practices.

• Familiarity with regulatory guidelines and quality control processes.
• Ability to manage multiple priorities in a fast‑paced environment.
• Experience with QQQ and QTOF instrument platforms (Sciex, Waters).

• Good hearing and communication skills.
• Vision (with correction) including color, distance, peripheral vision, depth perception, and the ability to adjust focus.
• Standing, reaching with hands and arms, and using hands and fingers to manipulate instrument or equipment controls, computer keyboard, office equipment, objects, or tools.
• Movement from one work location to another.
• Sitting and standing, sometimes for extended periods of time.
• Lifting objects up to 20 lbs.
• Exposure to intermittent or constant sounds generated by equipment.
• Exposure to fumes, noxious odors, and dust.
• Handling of biological material and blood‑borne pathogens.
• Handling of toxic or caustic chemicals.
• Proximity to moving parts.

We are an equal‑opportunity employer and will not discriminate against any employee or applicant for employment because of race, creed, sexual orientation, color, religion, sex, national origin, age, marital status, citizenship status, otherwise qualified disability, or protected veteran status (disabled Armed Forces Service medal, recently separated, active duty or campaign badge), domestic violence victim status, arrest record, or predisposing genetic characteristics.

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