PhD student; m​/f​/d

The Thimme/Hofmann lab, AG Röhlen, Department of Medicine II, Medical Center – University of Freiburg, is looking for a

We focus on translational research in the field of tumor immune escape in Hepatocellular carcinoma. Our results contribute to a better understanding of tumor- immune cell interactions with implications for therapeutic strategies.

The aim of this project is to comprehensively study the role of Cell Adhesion Molecules (CAMs) on structural cells such as fibroblasts and endothelial cells for tumor immune escape in Hepatocellular Carcinoma using high-dimensional immune cell profiling and patient-derived 3D model systems. Your work will give insights into the potential of Cell Adhesion Molecules as potential targets to overcome resistance to immunotherapy for the continously rising number of patients with hepatocellular carcinoma.

• a translational project in a clinically relevant setting with the possibility to implement your own ideas
• working in a dedicated interdisciplinary team of biologists and physicians on exciting research topics
• a unique network of excellent partners for continuous support in development of your scientific profile
• professional and efficient supervision supported by a thesis advisory committee
• a good working atmosphere in modern laboratories with cutting-edge equipment
• buddy System for new doctoral researchers
• participation in a wide range of further training opportunities and participation in (inter-)national conferences
• salaries are based on the German academic standards (TV-L, 65 %) with attractive employee benefits, e.g. Job Ticket UKF

• autonomous processing of research tasks related to immune escape in hepatocellular carcinoma
• working with 3D ex vivo models including tumor spheroids and organoids
• application of state-of-the-art and cutting-edge methods of cell and molecular biology including immunohistochemistry, imaging mass cytometry, high dimensional FACS
• establishing of new methods to elaborate on subsequent research questions
• presentation of results on regular lab and consortium meetings and (inter-) national conferences
• supervision of students

• we are looking for a highly motivated and enthusiastic individual who enjoys translational scientific work in an interdisciplinary and international team
• graduation (M. Sc.) in biology, molecular medicine or related subjects preferentially with focus on oncology and/or immunology
• strong interest in translational research, human immunology and oncology
• distinct working autonomy combined with a high capacity for teamwork
• a careful and focused working habit
• enjoy scientific work
• awareness of careful documentation
• ability to work independently and as a part of an international team
• communication skills in English
• knowledge in presentation skills

University Medical Center Freiburg

Clinic for Internal Medicine II

TEXIMMED2-FR

(Translational EXperimental IMmunology lab)

General information:
Salary is assigned according to a pay scale. Unless prevented by operational or legal reasons, full-time positions are generally open to those wishing to job share.

Where two candidates are equally suitable for a post, severely disabled candidates are given priority. Employment decisions are made by the Personnel Department.