Senior Therapeutics Discovery Technician

Overview

Please note that this position is contingent upon the successful award of a contract currently under bid.

Goldbelt Apex, a part of the Healthcare Technology Transformation Group, is a data-focused company dedicated to process and quality in every aspect. As experts in healthcare IT, Apex is committed to building systems for healthcare organizations to seamlessly communicate and exchange data across different systems and devices.

The Senior Therapeutics Discovery Technician shall provide senior laboratory support for research efforts of the MBD. Support shall be required in BSL-2, BSL-3 and BSL-4 environments. Contractor shall provide support in the planning and conduct of basic and applied research on current and emerging threats in support of the BD and infectious disease program.

• Assist in the planning, development, execution and evaluation of high-throughput screening projects for the antibacterial, anti-viral, and anti-toxin therapeutic areas and assist in the development of novel assays/methods for various programs. This includes basic cell culture to support these efforts. Shall assist in screening of molecular compound libraries for therapeutic efficacy to support MCM development.
• The Contractor shall perform both in vitro and in vivo microbiological experiments designed to evaluate therapeutic compounds for antibacterial/antiviral/antitoxin activity. In vitro assays include enzymatic assays, cell-based phenotypic and reporter assays. Minimum Inhibitory Concentration (MIC) and plaque assays. Shall perform standard molecular biology techniques to support development of these assays.
• The Contractor shall support mouse studies when required. Shall assist with inoculations of animals, collecting specimens for processing, and analysis of those specimens. Analysis may include development and conduct of immunological procedures including Enzyme Linked Immunoassay (ELISA), Western blot, and Mesoscale Discovery based assays.
• The Contractor shall assist in the preparation of technical reports, standard operating procedures, and manuscripts relating to their research efforts. The Contractor may be expected to present research findings at 1-2 scientific conference per year as needed and CONUS travel may be required. Contractor shall present results in written and oral format publicly and internally as requested.
• The Contractor shall be responsible for assessing and maintaining laboratory supplies in BSL-2, BSL-3 and BSL-4 laboratories. Shall assess supplies and ensure supply orders are coordinated with Division resources. Shall ensure that all assigned laboratory space is orderly and compliant with all regulatory guidance.
• The Contractor shall perform operations and training in animal manipulations. Contractor shall support animal studies (mouse, hamsters, guinea pigs, etc.) for funded projects. Contractor shall be experienced with handling both bacterial and viral pathogens for in vitro and in vivo studies with preferred experience in BSL-2, BSL-3 and BSL-4 biocontainment labs.
• Contractor shall provide the TPOC a Research Technical Report NLT the last day of each month.
• Contractor shall communicate to the Lead/PI or assigned TPOC as applicable, unexpected experimental data/results and assist in the troubleshooting or root cause analysis. Contractor shall communicate to the TPOC any laboratory or other work-related issues. Contractor shall communicate with internal maintenance or external vendors for technical support and troubleshooting.
• Contractor shall maintain an orderly laboratory environment in compliance with regulations. Contractor shall coordinate ordering of supplies with division staff. Contractor shall assist in training new personnel including students and other technicians as needed.
• Perform other duties as assigned.

Necessary Skills and Knowledge:

• Specialized skills may be required, including but not limited to, aerobiology, clinical pathology, electron or confocal microscopy, histopathology, quality assurance, and good laboratory practice.
• Ability to independently reads, understands, and executes techniques, procedures, and plans to meet…