Scientist, Translational Inflammation

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Gilead Sciences (Foster City, CA) is seeking a talented and highly motivated Translational Scientist to join our I
nflammation group and contribute to translational research in fibrotic and inflammation diseases such as IPF, IBD, RA, and NASH. Our collaborative and interdisciplinary research team utilizes state-of-the-art technologies and innovative methodologies to advance medicines into the clinic. The successful candidate is expected to be lab-based and to contribute to the discovery, research, development and implantation of novel biomarkers to support clinical advancement of therapeutic agents in the disease areas.

• Design and execute human‑relevant experiments in primary blood/tissue (gut, liver, skin, lung, synovium); perform responder vs non‑responder comparisons, perturbation studies, and pathway/target validation.
• High‑dimensional profiling: plan/execute high‑parameter flow or mass cytometry (≥18‑color), receptor occupancy and phospho‑flow; single‑cell (scRNA‑seq/ATAC) and spatial transcriptomics/proteomics; multiplex IF/IHC and quantitative pathology.
• Endotype & biomarker strategy: define disease‑agnostic PD/RO and endotype markers; qualify/validate fit‑for‑purpose assays (ELISA/MSD, qPCR/ddPCR, ligand‑binding, RO/TE) and transfer to internal labs/CROs under GCLP.
• Sample strategy & operations: contribute to protocol/IB biomarker sections; specify pre‑analytical handling, chain‑of‑custody and kitting; support CRO selection/oversight; ensure data integrity and timely delivery.
• Data integration & interpretation: partner with Biostats and Bioinformatics teams on analysis plans; integrate multi‑omic/imaging and clinical data; craft succinct go/no‑go narratives for governance.
• Influence without authority: coordinate across functions; document SOPs; contribute to safety/quality culture; mentor peers and have a growth mindset.
• Lead reverse translation work streams: interrogate clinical/real‑world datasets with Clinical, Biostats, and Bioinformatics; generate mechanistic hypotheses for response/non‑response.

Gilead Sciences is a world leader in antiviral research having developed small molecule compounds that have revolutionized the treatment of HIV, HCV, and HBV. Over the last 5 years, Gilead has significantly broadened its scope to encompass unmet medical needs in inflammatory and chronic fibrotic diseases.

Applicants must have a PhD or equivalent degree and at least 3 years of relevant post‑graduate independent research or drug development experience in immunology, fibrotic and autoimmune diseases. Experience and knowledge in human fibrotic and inflammatory diseases, immunology research is preferred. The candidate must demonstrate top expertise in previous research areas, critical analytical skills, experimental design and execution, and ability to lead independent hypothesis‑driven biological research, as exemplified by high quality publications.

Strong communication skills required. Working knowledge of…