Principal Scientist, Oncology Bioinformatics

Overview

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

We are seeking a highly talented and motivated Principal Bioinformatics Scientist to take a lead role in statistical analysis of multi-omics and next generation sequencing data to support research projects from target evaluation to biomarker discovery with a focus in immune oncology and cancer biology. The successful candidate will have the chance to work in a fast-paced and highly collaborative environment and impact high-level decision-making on internal pipeline and external collaboration.

The scientist will be responsible for developing and employing rigorous statistical modeling and cutting-edge bioinformatics methods to perform integrative large scale omics dataset analysis to enable research objectives. The successful candidate will be able to formulate scientific questions into coherent analytical efforts and communicate analysis results and scientific findings to project teams and across different research functions. This role will sit in Foster City, CA.

Responsibilities

• Develop and apply statistical and computational tools to analyze large scale omics and high dimensional data from internal, publicly available, commercial, and real-world datasets to enable novel target identification, target assessment, MoA elucidation, drug combination rationale, and patient stratification, etc.

• Design and apply statistical techniques and machine learning algorithms to enable the discovery and evaluation of preclinical predictive and prognostic biomarkers for oncology projects.

• Collaborate with cross-functional teams to analyze and interpret complex large datasets and efficiently communicate findings to non-computational scientists and senior leaders.

Qualifications

Basic Qualifications:

• Bachelor s Degree and Eight Years’ Experience

• OR

• Masters  Degree and Six Years’ Experience

• OR

• Ph.D.

Preferred Qualifications:

• Extensive hands-on experience in analyzing and interpreting RNA-Seq (bulk and single cell), WES, WGS, ATAC-Seq, CITE-Seq, and TCR-Seq data is required. The experience in analyzing other omics data (e.g., spatial transcriptome, Chip-Seq, MeRIP-seq, Nano String, multiplex qPCR, HT screening data sets) is a plus.

• Strong statistics knowledge, such as probability theory, univariate and multi-variable analysis, unsupervised and supervised analysis, regression analysis, survival analysis, feature selection, and power analysis. Excellent oral and written communication skills. Demonstrated capability to synthesize scientific questions into a coherent research effort and efficiently communicate scientific findings across different functional teams and present analysis results to project review teams and senior leader committees.

A proactive and self-motivated scientist with a strong work ethic and scientific rigor; ability to work in a dynamic environment and manage multiple projects in parallel and adapt to changing priorities. Demonstrated track record of producing high-quality scientific results as an individual contributor and a team member.

• A…