Sr Research Associate, Drug Metabolism

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

The primary responsibility of the Drug Metabolism and Pharmacokinetic (DMPK) Senior Research Associate role is to conduct absorption, distribution, metabolism, and excretion (ADME) studies to support the discovery and development of drugs candidates. As a member of the DMPK department, the candidate will conduct laboratory experiments (biochemical or cell-based) and bioanalysis (LC/MS and other methods), interpret data, and contribute to understanding of the ADME properties of small molecules.

Job Functions:

General knowledge of drug disposition processes for small molecules

Perform biochemical or cell-based assays to mechanistically investigate specific ADME issues

Under general supervision, design and execute complex experiments using appropriately selected methods and techniques to support routine research activities and project goals

Ability to troubleshoot and optimize assays as needed; identifying and applying novel techniques or protocols from reports in the scientific literature

Hands-on experience with quantitative analysis techniques with preference for HPLC-tandem mass spectrometric (LC-MS/MS) and/or high-resolution mass spectrometric (LC-HRMS) analysis

Working knowledge and hands-on experience working with physicochemical and/or biochemical assays using various human/animal tissue samples: solubility, metabolic stability, equilibrium dialysis; experience with primary hepatocytes (culture and/or suspension) preferred

Laboratory experience is essential

Capable to prioritize a diverse workload with strong time management skills

Ability to work productively in cross-functional teams, demonstrating strong interpersonal skills

Ability to communicate scientific results verbally and in writing

Ability to work in a collaborative enviornment

Excellent communication skills (both verbal and technical) and interpersonal skills are required.

Strong computer skills, including proficiency with basic data analysis programs (Excel, Graphpad Prism, etc)

Basic Qualifications:

2+ years with a BS degree in pharmacology, pharmaceutical sciences, cell biology, biochemistry

or

0+ years with a MS degree in pharmacology, pharmaceutical sciences, cell biology, biochemistry, or related experience in industry

Job Description

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure…