Director, Drug Metabolism; Biotransformation

Position: Director, Drug Metabolism (Biotransformation)
Job Description

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

The primary responsibility of this position is to lead biotransformation activities in the Drug Metabolism Department and in collaboration with the Clinical group. The scientist will be the subject matter expert and provide strategy/guidance to project teams for advancement of candidate compounds. This job role will focus on metabolite profiling and characterization of those compounds in vitro and in vivo to understand metabolic pathways to support drug discovery and development.

More broadly, the scientist is expected to integrate this information with absorption, distribution and excretion data for candidate compounds for a full understanding of their drug metabolism and pharmacokinetic (PK) behavior. This will include representation of the department on multidisciplinary project teams. Supervision and mentoring of other scientists and/or laboratory staff will be required. This role will be based in our headquarters in Foster City, CA.

Essential Duties and

Job Responsibilities:

Work closely with internal and external resources to assure high quality and timely delivery of nonclinical and clinical biotransformation data for molecules in discovery and development, including 14C mass balance studies.

Design and perform complex analyses to characterize biotransformation and disposition of candidate drugs.

Serve as a drug metabolism and biotransformation subject matter expert for multiple dynamic cross-functional teams, to define strategies to achieve target product profiles, integrate in vitro and in vivo drug disposition data, interpretation, and give presentations to teams.

Provide clear verbal communication of results and strategies at group, department, project team and management level. Write research reports and regulatory documents.

Contribute to science through conference presentations and publication of new findings.

Basic Qualifications:

Bachelor's Degree and Twelve Years’ Experience

OR

Masters' Degree and Ten Years’ Experience

OR

PhD and Eight Years’ Experience

Preferred Qualifications:

A highly motivated individual with PhD degree in life sciences withyears of post-doctoral and/or industry experience directly related to the Specific Responsibilities listed above (hands-on experience and deep knowledge of biotransformation and structure elucidation).

Considered an expert in metabolic routes of biotransformation and metabolite identification demonstrated through presentation/publication.

Comfortable working with and educating colleagues in drug metabolism, toxicology and clinical pharmacology departments, on strategies to understand drug metabolism and disposition.

Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.

Expertise and experience in one or more of the following areas:

Lead design and execution of nonclinical and clinical radio- and non-radio labeled ADME studies. Serve as an expert resource; to ensure…