Associate Director, Biostatistics

We are taking genetic medicine to new heights and into new disease areas to overcome challenges not addressed by existing medicines. This incredible challenge drives our relentless and talented team. Our people are the essence of our inspiring, innovative and collaborative environment that encourages individual contributions and provides opportunities for career development.

Our company is centered on our guiding principles. They direct every facet of our work, culture, hiring and drive to scale our world‑class genetic medicines company.

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DMT champions diversity, equity and inclusion every single day. Our employee‑led Diversity efforts are inspired by our guiding principles to focus awareness on social equity and create positive change not only within 4

DMT, but in our community  also seek to embrace our patient populations so we can help raise awareness.

We have had great success in our community partnering with charitable organizations.

We are focused on hiring, inspiring and supporting the best people in the industry who identify with our vision. We create an exciting, dynamic and collaborative environment that fosters dedication to visionary science and medicine, recognizes performance, offers generous benefits and provides challenging opportunities for career development. Join us in creating the future of genetic medicine.

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DMT is a leading late‑stage biotechnology company advancing durable and disease‑targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D‑150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi‑year sustained delivery of anti‑VEGF (aflibercept and anti‑VEGF‑C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections.

The Company’s lead indication for 4D‑150 is wet age‑related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D‑710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery.

The Associate Director, Biostatistics provides strategic input and technical expertise on statistical methodology to lead assigned projects. They will participate as active members of a cross‑functional team to plan, lead and execute the tasks required to support the assigned programs. The incumbent will collaborate closely with cross‑functional teams and external vendors.

• Provide statistical expertise and collaborate with various functions on study design/planning, protocol development, statistical methodology/analysis.
• Responsible for the development of statistical analysis plan (SAP), TFL shells and other analysis specifications on assigned studies.
• Responsible for the development of randomization schema on assigned randomized studies.
• Perform data analysis and/or collaborate with statistical programming (in house or vendor) to ensure quality analysis conducted per the SAP and specifications.
• Responsible for the development of statistical reports summarizing the data analysis results.
• Ensure adequate interpretation of data/analysis results and consistency/accuracy of data presentation for study reports and publications.
• Collaborate with various functions to ensure robust CRF/EDC development, and quality data collection for the assigned clinical trials.
• Provide quality review of outsourced statistical deliverables (including in‑house double programming to QC as needed) and coordinate the in‑house review comments.
• Stay abreast of industry development in biostatistics/statistical programming fields and apply to appropriate systems and processes.
• Other duties as assigned; nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.