Vice President, Supply Chain

Overview

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DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections.

The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery.

The Vice President, Supply Chain is responsible for the end-to-end strategy, execution, and governance of global supply operations across all phases of development. This role ensures uninterrupted, compliant, and cost-effective supply of investigational and commercial products, comparators, ancillaries, and open-label therapies to support global clinical trials and commercial launch.

This leader will build and scale a best-in-class supply organization, partner closely with Clinical Operations, CMC, Regulatory, Quality, and external vendors, and provide senior level oversight of supply risk, forecasting, and readiness in support of critical development and registration milestones.

• Define and execute the global supply strategy across early- and late-stage programs, including Phase 1–3, commercial launch, and post-approval commitments
• Serve as the enterprise leader for clinical trial supply governance, risk management, and scenario planning
• Provide senior-level input into development timelines, enrollment strategies, and global expansion plans based on supply feasibility
• Anticipate and proactively mitigate supply risks (manufacturing capacity, comparator shortages, import/export constraints, depot limitations, based on deep experience with global supply chain)
• Drive BLA-enabling supply chain activities, including shipping validation, planning for commercial labeling processes, and temperature monitoring strategies. Provide support for combination device strategy (such as co-packaging with needles and syringes, pre-filled syringes, and other approaches, including device compatibility strategies), and launch forecasting and planning.

• Oversee end-to-end clinical supply execution, including:
• Demand forecasting and supply planning
• Packaging, labeling, and distribution
• Depot strategy and inventory management
• Open-label and rescue medication sourcing (e.g., comparator biologics)
• Management of drug product inventory, including production needs, regulatory timing, and QP approval for introduction of new lots
• Balance supply needs with financial ones, including management of cost, expiration dating, potential delays, and clinical enrollment projections
• Ensure timely and compliant supply to global investigational sites while supporting enrollment acceleration and protocol amendments
• Lead contingency planning for constrained supply scenarios and high-enrolling sites

• Select, manage, and govern global supply vendors (CMOs, depots, couriers, comparator sourcing partners), and work closely with global CROs (pack and label vendors, clinical trial vendors) to ensure smooth uptake in new countries
• Establish performance metrics, KPIs, and escalation pathways to ensure vendor…