Scientist - Purification Sciences; Downstream PD

Description

We are seeking a Scientist I – Purification Sciences to support downstream process development activities for a growing biopharmaceutical pipeline. This individual will be part of a collaborative technical operations team responsible for developing, optimizing, and scaling purification processes for biologic molecules, including monoclonal antibodies and bispecific antibodies.

The role is highly hands‑on and execution‑focused, with primary responsibilities centered on laboratory‑scale chromatography and filtration experiments, along with associated lab preparation, documentation, and cross‑functional collaboration. Opportunities may also include support of process scale‑up and pilot‑scale activities.

• Prepare buffers and solutions to support downstream purification experiments
• Calibrate and maintain pH and conductivity meters and other routine lab equipment
• Execute chromatography experiments using AKTA systems (AKTA Avant experience preferred)
• Perform protein concentration measurements and analytical sample preparation
• Execute tangential flow filtration (TFF) experiments; high‑concentration TFF experience is a strong plus
• Perform viral filtration and other normal‑flow filtration operations
• Collect, label, and submit samples to analytical teams for testing
• Document experimental work in compliance with Good Documentation Practices (GDP)
• Analyze process data and contribute to technical reports and summaries
• Collaborate closely with cross‑functional teams, including upstream, analytical, and pilot/scale‑up groups
• Support a fast‑paced laboratory environment by managing multiple experiments in parallel

• Bachelor’s degree with 4+ years of relevant industry experience, or
• Master’s degree with 2+ years of relevant industry experience, or
• PhD with relevant hands‑on laboratory experience

• Downstream Purification, AKTA, Tangential Flow Filtration, buffer preparation, GDP

• Hands‑on downstream purification experience for biologics (mAbs, bispecifics, or similar modalities)
• Practical experience operating AKTA chromatography systems
• Tangential flow filtration (TFF) and filtration process experience
• Strong understanding of buffer preparation, solution chemistry, and lab fundamentals
• Experience working in a regulated or GDP‑compliant laboratory environment
• Ability to troubleshoot experiments and adapt to changing priorities
• Strong organizational, communication, and collaboration skills
• Comfortable working in a dynamic, team‑oriented biotech setting with shared ownership of lab responsibilities

Intermediate Level

This is a Contract position based out of Durham, NC.

The pay range for this position is $40.00 - $50.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre‑tax and Roth post‑tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long‑term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type:
This is a fully onsite position in Durham, NC.

Final date to receive applications:
This position is anticipated to close on Mar 20, 2026.

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email actalentaccom for other accommodation options.