Intern, Translational Modeling

COMPANY: At Bio Cryst, we share a deep commitment to improving the lives of people living with hereditary angioedema (HAE) and other rare diseases. We leverage our expertise in structure-guided drug design to develop first-in-class or best-in-class oral small-molecule and injectable protein therapeutics, led by the efforts of our team of expert scientists in our Discovery Center of Excellence in Birmingham, Alabama.

Our global headquarters is in Durham, North Carolina and our employees span the globe across sites in multiple countries. We are proud of our culture of engagement and accountability that rewards people for innovative thinking and achievement of key objectives. For more information, please visit our website at  or follow us on Linked In and Instagram.

The Bio Cryst Internship Program is more than just an internship, it's a launchpad for your future career. We believe the best learning happens through hands‑on experience, meaningful connections, and ownership of your summer projects. During your 12‑week internship, you'll dive into biotech projects firsthand and see the impact your work has on patient lives.

• Hands‑On Work:
  Participate in projects that have real impact on the team and company.
• Onboarding & Orientation:
  Kick off the summer with an in‑person orientation at our headquarters to meet fellow interns and leaders.
• Professional Growth:
  Attend workshops, networking sessions, and join the Career Connections Program to sharpen your skills and explore career paths.
• Community & Culture:
  Join social events, team‑building activities, and volunteer opportunities to build relationships and give back.
• Intern Showcase:
  Share your work and impact at our in‑person Summer Intern Showcase.
• Access to Leaders:
  Gain insights directly from company leaders and innovators shaping the future of biotech.

The Translational Modeling Team in Nonclinical Development is seeking an exceptional student in pharmacology, biomedical engineering, chemical engineering, or a related field. The ideal candidate will be passionate about using mathematical modeling approaches to accelerate the design and development of new therapies for patients. This internship offers the opportunity to learn and apply various modeling techniques, including PK/PD, PBPK, QSP, and pathway modeling, to enhance drug development in accordance with MIDD regulatory guidelines.

Working in a dynamic and highly collaborative environment with industry leaders, the selected student will gain valuable industrial experience that will significantly boost their future career prospects.

#LI-REMOTE

• Design, implement, calibrate, validate, and document mechanistic modeling approaches to address specific MIDD questions.
• Develop custom PBPK models for protein therapeutics, fit‑for‑purpose QSP models, and detailed pathway models.
• Collaborate with scientists across different departments to ensure the proposed models provide accurate and timely solutions.
• Present modeling results and recommendations at various departmental meetings.

• PhD student in pharmacology, chemical, mechanical or biomedical engineering, biochemistry, physics, applied mathematics, bioinformatics, scientific computing, or related field.
• Proficiency in scientific computing and programming, with a strong preference for experience in Matlab and Sim Biology.
• Experience in developing mechanism‑based mathematical models of biological systems.
• Preference for experience with PBPK and QSP modeling.
• Experience in leveraging AI technologies to improve modeling workflows is a plus.
• Excellent written and oral communication skills.
• Scientific curiosity and the ability to provide creative solutions to scientific problems.
• Ability to travel to the Durham/RTP and/or Birmingham office – on‑site presence may be required for meetings and intern program activities.

• Duration: 12 weeks.
• Program Dates: May 18, 2026 – August 7, 2026.
  * start and end dates are NOT flexible.
• Expected weekly hours: 32‑35
• Location: Local to Durham, NC or Birmingham, AL preferred. Can be remote, but must be able to…