Staff Scientist - Analytical Pharmacology Core Facility

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life‑threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting‑edge research.

The Beckman Research Institute of City of Hope is looking for a talented Staff Scientist to perform several functions as a member of the Analytical Pharmacology Core Facility. Your primary role will include operation of the liquid chromatography tandem mass spectrometry (LC‑MS/MS) instrumentation available in the core. These efforts will include not only operating the instrument but also assay development, sample preparation, calibration, data analysis, data management/backup and routine maintenance/troubleshooting.

In addition, you will assist the director with the development and validation of new analytical methods for the quantitative analysis of large and small molecules in support of pharmacokinetic and biomarker investigations.

• Develop and apply new and established LC‑MS/MS and ICP‑MS analytical methods.
• Perform data analysis, maintain records, report analytical results, prepare Standard Operating Procedures (SOPs) for sample preparation and analysis, and assist in manuscript preparation for publications.
• Perform preventative maintenance and troubleshooting of problems with laboratory equipment.
• Consult with core users regarding appropriateness of analytical methods and experimental design.
• Coordinate sample collection and batch preparation together with other lab staff.
• Participate in and present findings at weekly lab meetings and provide cross‑training to other lab members.

• Ph.D., Pharm.
  
  D. or M.D./Ph.D. degree in Pharmacology, Analytical Chemistry, Life Sciences or related discipline with a background within preclinical and clinical pharmacokinetic studies. A Master’s degree with a minimum of 3 years of experience in an analytical laboratory will also be considered.
• Previous experience using LC‑MS/MS instrumentation for quantitative analysis of large and small molecules required.
• Experience with Waters and/or AB Sciex instruments is particularly desirable.
• Experience with ICP‑MS analyses using an Agilent system is also desirable.
• Other important skills include knowledge of analytical chemistry and experience with instrument controller software programs, like Mass Lynx® and Analyst®.
• Knowledge of the principles of quantitative analysis and familiarity with the FDA’s Biomedical Method Validation Guidance for Industry are also preferred.
• Strong interpersonal, documentation, and organizational skills, and a commitment to providing high‑quality analytical chemistry services for users of the core facility are essential.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

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