Research And Development Associate

Job Overview :

We are seeking a highly motivated  Research Associate / Scientist  to join our  Cell and Gene Therapy (CGT) Projects . The role involves hands-on research in  immune cell engineering ,  process development , and  functional characterization of engineered cells , while working closely with cross-functional teams including  Preclinical, GMP Manufacturing, Quality, and Regulatory Affairs .

This is an exciting opportunity to contribute to cutting-edge immuno-oncology and Build a good Career into CGT Domain & translational research programs.

Suitable Profiles :
PhD / M.Sc. / M.Tech in  Life Sciences, Biotechnology, Biochemistry, Biology, or related disciplines
2–5 years  of relevant research experience
Strong foundation in  Immunology, Cell Biology, and Molecular Biology

Roles and Responsibilities
Design, plan, and perform laboratory experiments related to various immune cell engineering and the development of robust manufacturing processes for cell therapy products.
Manage and execute immune cell culture and differentiation, including primary cell culture, cell line maintenance, and gene modification techniques (e.g., using lentiviral vectors, CRISPR-Cas9 systems, etc.).
Prior experience in generation of lentiviral vectors, viral infection of primary cells and advanced molecular biology techniques, including gene editing techniques will be preferred.
Develop and perform a variety of cellular and molecular assays for the functional characterization and phenotyping of the engineered cells, using flow cytometry, ELISA, qPCR, ddPCR, live-cell imaging, metabolic health assessments and co-culture set-ups for cytotoxicity testing.
Accurately collect, record, analyze, and interpret experimental data. Use statistical analysis (e.g., Design of Experiments/DoE) to determine critical process parameters.
Be able to troubleshoot experiments, analyse data and interpret scientific presentations.
Ensure all research activities comply with regulatory requirements.
Identify, analyze, and resolve technical issues during research and process development, implementing process improvements.
Present research findings, project progress, and scientific strategy to stakeholders, potentially including external collaborators or conferences.
Involve in projecting requirements, interacting with vendors, and engaging in the pipeline of procuring new consumables and equipment required for the project.
Work closely within highly matrixed, cross-functional teams and mentor junior scientists or research associates to advance company’s Cell and Gene therapy pipeline.
Communicate effectively to interface with internal functional departments to support the workflow of various study-related activities.
Coordinate with Preclinical, GMP manufacturing, Quality control, Quality assurance and supply chain teams and strictly adhere to project timelines by preserving integrity, accuracy, safety and quality.
Actively engage in non-GMP validation and IND filing studies.
Prepare and involve in compliance monitoring inspections and regulatory agency interactions.
Understand systems and process pertaining to sterile practices, work ethics, safety, health and environment.

Competencies
PhD / M.Sc. / M.Tech in  Biology, Biotechnology, Biochemistry , or related fields
Coursework in  Cell Biology, Immunology, Molecular Biology
Strong expertise in  T-cell or NK-cell biology , immuno-oncology, and CGT processes
Hands-on experience in:
Aseptic processing
Flow cytometry
Live-cell imaging
qPCR / ddPCR
Viral transduction
Molecular biology techniques
Problem Solving
Excellent analytical and critical thinking skills to resolve complex scientific and process-related challenges
Strong written and verbal communication skills
High attention to detail and organizational abilities
Ability to work efficiently in a  fast-paced, collaborative environment
Strong documentation and record-keeping skills in line with regulatory and quality standards