Junior Specialist; McKenney Lab
Listed on 2026-03-01
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Research/Development
Research Scientist, Data Scientist, Clinical Research, Research Assistant/Associate
Position overview Salary range: A reasonable estimate for this position is $55,000 at Step 1 (@ 100%) or $58,600 at Step 2 (@ 100%)
Junior Specialist NEX: A reasonable estimate for this position is $26.35/hr at Step 1 or $28.07/hr at step 2 Application Window
Open date: December 2, 2025
Most recent review date: Wednesday, Dec 17, 2025 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.
Final date: Tuesday, Jun 30, 2026 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
Junior Specialist Position in Alzheimer's Disease and Tau Biology
The Department of Molecular and Cellular Biology at the University of California, Davis invites applications for one Junior Specialist in cell biology and neurodegeneration research.
Position Description
A Junior Specialist position is available immediately in the lab of Dr. Richard McKenney in the Department of Molecular and Cellular Biology at UC Davis. The successful candidate will support ongoing research projects focused on understanding the molecular mechanisms of tau protein dysfunction in Alzheimer's disease and related tauopathies under the general guidance and supervision of the Principal Investigator. The position will utilize state-of-the-art single-molecule imaging, biochemical reconstitution, and cell-based assays to investigate how pathological tau phosphorylation patterns disrupt normal tau-microtubule interactions and promote tau aggregation.
Work will include, but not be limited to:
- Single-molecule fluorescence microscopy of tau dynamics on microtubules
- Biochemical reconstitution of tau-microtubule interactions using purified components
- Generation and characterization of phosphorylated tau variants
- Cell-based assays using authentic Alzheimer's disease brain-derived tau filaments
- Quantitative image analysis and biophysical modeling
This position offers an excellent opportunity to gain hands-on experience at the interface of basic cell biology and translational Alzheimer's research, with direct access to patient-derived samples through collaboration with the UC Davis Alzheimers Disease Research Center.
Responsibilities
Research (85%)
Conduct experiments under the guidance of the PI using techniques including protein expression and purification, single-molecule fluorescence microscopy (TIRF), tau aggregation assays, and live-cell imaging
Perform quantitative analysis of tau dynamics, microtubule interactions, and aggregation kinetics
Collect, organize, analyze, and present data in group meetings
Maintain detailed experimental records, notes, and laboratory documentation
Assist the Principal Investigator with preparation of high-quality peer-reviewed manuscripts and grant submissions
Collaborate with researchers at the UC Davis Alzheimers Disease Research Center and other institutions as directed by the PI
Professional Competence (15%)
Provide technical assistance and mentoring for junior researchers (graduate students and undergraduates) as appropriate
Maintain lab stocks, reagents, and databases
Contribute to lab maintenance and organization
Assist with equipment maintenance and optimization of microscopy platforms
Questions
Please direct questions to Richard McKenney, rjmckenney
To Apply:
(Use the "Apply for this Job" box below)./JPF
07418
Qualified applicants should upload:
- Cover letter describing research interests and career goals
- Statement of relevant research experience and technical skills
- Curriculum vitae
- Contact information for three references
Bachelor's degree in cell biology, biochemistry, biophysics, neuroscience, or related field, OR equivalent research experience (minimum 12 months in a research laboratory). Demonstrated experience with fluorescence microscopy techniques is required.
Candidate must be able to keep a complete and detailed laboratory notebook of experimental procedures and data and to archive and document reagents and data for publications and presentations.
Strong organizational skills, attention to detail, and ability to follow protocols and procedures are essential. The ideal candidate will have strong interpersonal and communication skills and the ability to work well both independently and as part of a team under the guidance of a supervisor.
Additional qualifications (required at time of start)Demonstrated ability to execute experimental protocols and learn new techniques with guidance from the PI
Strong written and oral communication skills
Ability to perform basic quantitative data analysis using software such as Image
J/Fiji, Excel, or similar platforms
Basic understanding of laboratory safety and ability to work with biohazardous materials following appropriate safety protocols
Willingness to work flexible hours as needed for time-sensitive experiments (e.g.,…
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