Research Associate, Proteomics & Flow Cytometry

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Job Title:

Research Associate, Proteomics & Flow Cytometry Department: CCC | Immune Monitoring and Discovery Platform

The Researcher 1 will support the research laboratories of Drs. Zihai Li and Tim Zhang within the OSUCCC – James Pelotonia Institute for Immuno-Oncology (PIIO). This position will contribute to integrated experimental and computational studies focused on protein homeostasis, immune cell function, and cancer immunotherapy, with a strong emphasis on experimental and computational proteomics.

The research program seeks to define how proteotoxic stress responses and protein quality control mechanisms shape immune cell biology, including T cell dysfunction and exhaustion in cancer, and to leverage proteomic technologies and data-driven approaches to identify novel therapeutic targets. The Researcher 1 will participate in the planning, execution, and analysis of interdisciplinary projects that combine wet-lab experimentation with quantitative proteomic and bioinformatic strategies.

• Participate in the planning and execution of research projects using molecular and cellular biology techniques, including tissue culture, SDS-PAGE, western blotting, PCR, immune cell isolation, mouse handling and injections, and proteomics sample preparation. (35%)
• Support experimental and computational proteomics workflows, including sample processing, data organization, quality control, and coordination with mass spectrometry and bioinformatics pipelines. (15%)
• Collect, analyze, and interpret experimental and proteomic datasets; assist in the development and implementation of new experimental or computational methodologies. (15%)
• Perform literature reviews and contribute to manuscripts, grant proposals, and scientific presentations related to immunology, proteostasis, and proteomics-based discovery. (15%)
• Monitor and enforce laboratory safety procedures; ensure compliance with institutional, biosafety, and federal regulations. (10%)
• Train research staff and students as needed and assist with daily laboratory operations, including procurement, inventory, and equipment maintenance. (10%)

• Bachelor’s degree in biological sciences, biochemistry, computational biology, bioengineering, or a related field, or equivalent experience.
• Ability to translate and apply academic knowledge in biological and quantitative research environments.
• Experience in a research capacity preferred, particularly in immunology, proteomics, molecular biology, or data-driven biology.
• Strong analytical, organizational, and communication skills.

Proficient knowledge of immunology. Demonstrated success in training and supervising others. Demonstrated experience with data analysis platforms and making figures suitable for scientific presentations (e.g., Flow Jo, DiVa, Omiq), Microsoft Office products (e.g., Word, Excel, PowerPoint), and other common tools. Training in bacteriological, viral, chemical, and physical safety. Proficiency with Macintosh or PCs and handheld devices. Able to work safely in a BSL2 environment.

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