Rare Disease Specialist

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Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein.

Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics.

Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking experienced and driven Cardiovascular Rare Disease Specialists (RDS) to join our growing commercial team. This is a rare opportunity to play a pivotal role in the commercial launch of Arrowhead’s leading investigational cardiometabolic medicine – Plozasiran (siRNA targeting APOC3). This product has demonstrated compelling clinical data to date and is in late-stage development for the treatment of various grievous conditions, including Familial Chylomicronemia Syndrome (FCS) and Severe Hypertriglyceridemia (SHTG).

Over time, this role could expand to cover additional indications and products in the Arrowhead cardiometabolic portfolio.

Responsibilities

• Territory & Account Management
• Develop and execute strategic business plans to exceed territory sales goals.
• Build and sustain impactful relationships with healthcare professionals, key opinion leaders (KOLs), and institutional decision-makers (IDNs, hospital systems).
• Ensure consistent, high-quality engagement and service across accounts to drive adoption and utilization.
• Stakeholder Engagement
• Navigate complex healthcare systems and decision-making processes within large institutions.
• Demonstrate agility and resilience in managing stakeholder relationships in fast-paced settings.
• Cross-Functional Collaboration
• Partner with internal teams—including Marketing, Medical Affairs, Market Access, and the Patient Hub—to align field efforts with company strategy.
• Act as the voice of the field, providing valuable insights to internal commercial team.
• Travel & Engagement
• Represent Arrowhead at key conferences, regional/national meetings, and training sessions (~30% travel required).
• Overnight travel may be necessary depending on territory.

Requirements:

• 5 years of pharmaceutical sales experience, with 3+ years in rare disease or cardiovascular specialty preferred.
• Demonstrated success in specialty sales involving complex therapies and access navigation.
• Background in cardiology or related specialties is highly desirable
• Strong territory planning and account management capabilities.
• Excellent communication, presentation, and relationship-building skills.
• Ability to manage competing priorities in a dynamic and competitive environment.
• Solid understanding of the rare disease or cardiovascular landscape.
• Equity (RSUs) and car allowance program
• Comprehensive benefits package; health, dental, vision, and 401(k)

$130,000—$170,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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• Seniority level
  
  Mid-Senior level

• Employment type
  
  Full-time

• Industries Biotechnology Research and Pharmaceutical Manufacturing

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