Scientist II, Process Development - Upstream

Scientist II, Process Development - Upstream

Columbus, OH

Forge Your Future with Us:

At Forge Biologics, we believe in turning bold ideas into life‑changing realities. Our mission is simple yet powerful: to enable access to life‑changing gene therapies and help bring them from ideas into reality. We partner with scientists, physicians, biotech and pharma innovators, and patient communities — all united by one goal: improving lives. Ifyou’redriven by purpose and excited to make a tangible impact, this is where your journey begins.

Our Team works out of The Hearth, a state‑of‑the‑art, 200,000‑square‑foot cGMP facility in Columbus, Ohio. Here, you won’t just watch innovation happen — you’ll be part of it. Whether you’re scaling AAV manufacturing, collaborating on cutting‑edge therapies, or supporting complex technical projects, you’ll play a key role in bringing hope to patients with genetic diseases.

What sets Forge apart is our culture of H.O.P.E. We are hardworking
, showing up each day with determination and grit. We are open
, creating a space where ideas flowfreelyand every voice is valued. We are purpose‑driven
, with every task directly tied to changing lives. And we are engaged
, energized by the challenges we face and the milestones we achieve together.

At Forge, your growth matters.

We’recommitted to helping you expand your skills, take on new challenges, and develop your career through mentorship, hands‑on learning, and opportunities for advancement. Our people are our greatest investment, andwe’reproud to see team members grow with us.

Ifyou’reready to use your talent to help deliver hope to patients around the world, join us — and be part of something bigger than yourself.

About The Role:

The Scientist

II provides active leadership and execution ofthe laboratoryexperiments and protocols for upstream process development efforts. This individual will leadprojects and complex experiments,trainjunior scientists, and actively contribute to the advancement of AAV manufacturing processes.

Responsibilities:

• Senior‑level technical contributor and subject matter expert for upstream systems and process strategy
• Independently manages multiple projects or client programs simultaneously, maintaining a high degree of quality, scientific rigor, and compliance
• Leads process development activities for early‑to‑late‑stage programs, including scale‑up, technology transfer, and validation support
• Designs and executes complex DoE studies, authors technical reports, and contributes to regulatory documentation
• Anticipates challenges in upstream scale‑up and proactively develops solutions to ensure technical success
• Acts as a key liaison between Process Development, Manufacturing, and Quality teams to align on strategy and ensure smooth GMP execution
• scientific rationale for tech transfer packages and GMP documentation without owning official SOPs or batch records
• Mentors junior scientists and associates through day‑to‑day technical guidance, fostering development in experimental design, documentation standards, and scientific reasoning

Qualifications:

• Bachelor’s Degree in Chemical Engineering , Bio e ngineering, Biology, or related discipline (or equivalent experience)
• Working knowledge of cell culture techniques utilizing mammalian cells
• Proven ability to operate and troubleshoot bioreactors
• Experience planning, conducting and reviewing experimental data with minimal oversight
• E xperience training and development of other team members
• Experience analyzing data sets and utilizing the corresponding data to influence decision making
• E xperience working with external collaborators (clients, external technology transfers, etc. )

Preferred

Skills:

• Master’s Degree or PhD in Chemical Engineering, Bio e ngineering, Biology, or related discipline (or equivalent experience)
• Experience working with viral vectors (AAV, Lentivirus, etc.)
• Experience in late‑stage process development , process characterization , risk assessments (e.g., FMEA )
• Buffered experience with Am ® 250 and other bench‑scale bioreactor systems
• Hands‑on e xperience in design of experiments and with statistical software (e.g., JMP)

This job description is not designed to cover or…