Director, Chemical Biology

Site Name: USA - Pennsylvania - Upper Providence

Posted Date: Jan 16 2026

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture which is ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success.

We’re uniting science, technology, and talent to get ahead of disease together.

You will lead the chemical biology team in Upper Providence (UP) and will report directly to the global head of Chemical Biology. The Chemical Biology team is accountable for the identification and characterization of tool molecules, which support target identification and validation in complex “in vitro” models and inform modality selection for early discovery programs.

This role will provide you the opportunity to lead key activities to progress your career; these responsibilities include the following:

• Develop and lead a high‑performing chemical biology team at our UP site, foster a culture of collaboration and continuous learning and grow capabilities in line with global strategy.
• Work as part of the chemical biology global leadership team to set scientific strategies, establish prioritization and resource plans aligned to program goals and drive delivery of chemical biology capabilities to support discovery programs.
• Provide strong scientific leadership and be accountable for managing team execution, ensuring reproducible, well‑controlled experiments with clear data interpretation.
• Collaborate effectively across functions, including in a project team setting, to translate biological understanding into robust target nominations.
• Communicate progress, risks and recommendations clearly to stakeholders and governance bodies and represent Chemical Biology in technical review meetings.
• Monitor technology development in the external environment and, where appropriate, bring technology into GSK or facilitate technology development in house.

We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• Advanced degree (PhD preferred) in chemical biology or related discipline, such as chemistry, biochemistry or molecular cell biology.
• At least 10 years of relevant industry experience in chemical biology, drug discovery or related research.
• Experience of project and people leadership including hiring, mentoring and developing talent.
• Experience with chemical probe development and target deconvolution.
• Experience of collaborating across scientific/technical disciplines and/or organizational divisions and influencing senior stakeholders and/or higher organizational strategy.
• Track record of scientific publications or contributions to peer‑reviewed literature.

If you have some of the following characteristics, it would be a plus:

• Experience of pharmacology and mechanistic biology, including but not limited to the study of covalent binders, degraders and antibody‑drug conjugates.
• Excellent communication skills for developing/articulating scientific strategy, risk mitigation plans, and milestones which can be exemplified through presentations at stakeholder meetings.
• Experience of high‑content biology approaches, such as imaging, proteomics/transcriptomics.
• Experience of target identification and/or validation.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful,…