Principal Scientist; Renal Disease

Overview

Site Name: USA - Pennsylvania - Upper Providence

Posted Date:
Jan 21 2026

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients  needs and have the highest probability of success.

We re uniting science, technology, and talent to get ahead of disease together.

Find out more:
Our approach to R&D

As a Principal Scientist in the Biology Unit, working in Renal Disease, you will play a critical role in bridging preclinical and early clinical proof of concept studies by designing and performing validation and translational assays in human-derived cells, tissues, and biofluids.

This is a lab-based position with mandatory on-site presence at the Upper Providence, Pennsylvania (USA).

• Design and execute laboratory experiments to advance scientific understanding and support drug discovery in renal disease.
• Support identification and validation of new targets and development of translational assays.
• Apply expertise in multiple capabilities such as ELISA/MSD, Western/JESS, flow cytometry, gene/protein expression analysis, proteomics, and other omics platforms.
• Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design.
• Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.

We are looking for professionals with these required skills to achieve our goals:

• M.S. + 5 or more years of experience or PhD +3 or more years of experience within a scientific discipline (preferably renal or related field) with relevant laboratory experience.
• Three or more years of experience with handling of primary human cells and laboratory techniques such as immunoassays (ELISA, MSD), qPCR, multi-color flow cytometry, and gene expression analysis.

If you have the following characteristics, it would be a plus:

• One or more years of experience in Renal disease.
• Excellent problem-solving skills and ability to critically analyze scientific data.
• Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.
• Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.
• Able to independently define strategic approach to tackle specific project or department goals.
• Ability to work independently as well as collaboratively in a team-oriented environment.
• Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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