Director, Portfolio Decision Sciences

Site Name: UK - London - New Oxford Street, USA - Pennsylvania - Upper Providence

Posted Date:
Jan 27 2026

GSK is seeking a highly skilled and visionary Director, Portfolio Decision Sciences to partner with the Head, Portfolio Decision Sciences, Oncology in supporting GSK's Oncology and broader Pharmaceutical portfolio across the entire R&D lifecycle—from preclinical research through latestage clinical development.

In this influential role, you will work directly with project teams and governance boards to evaluate investment opportunities in areas of high uncertainty and limited data, guiding technical progression and investment decisions through systematic risk assessment, probabilistic evaluation, and rigorous economic analysis (e.g., ROI, NPV). Your insights will inform key decision‑making bodies including the Portfolio Investment Board, Development Review Board, and Research Unit Investment Boards.

• Guide project teams across the R&D lifecycle using strategic decision frameworks, probability of success elicitation, and economic evaluations (ROI, NPV).
• Deliver objective project assessments for R&D investment decisions at governance bodies including the Portfolio Investment Board.
• Provide rigorous recommendations to governance chairs based on detailed value‑risk analyses, option evaluations, resource considerations, and risk discharge points.
• Lead portfolio or indication‑level assessments to inform senior leaders on prioritisation decisions across scientific, commercial, operational, strategic, and financial dimensions.
• Support the biannual dynamic Portfolio Review for Oncology, refreshing project assessments and surfacing emerging investment opportunities.
• Collaborate across finance, portfolio management, strategy, operations, and Research Units to recommend short‑ and long‑term focus areas and enable optimal resource deployment.
• Drive portfolio management excellence by monitoring the external environment, evaluating innovative portfolio approaches, and proposing use cases applicable to GSK.
• Enhance the development and deployment of advanced analytics, including AI and machine learning, to elevate decision‑making quality across teams and senior leadership.

• Bachelor’s degree in Science or Business.
• PhD, MD, or advanced scientific/decision‑sciences degree preferred.
• Demonstrated experience in pharmaceutical, healthcare, or related industries.
• Strong understanding of R&D processes, ideally with experience supporting or leading drug‑development teams.
• Proven track record of independently delivering complex projects.
• Experience navigating cross‑functional teams and enabling change.
• High learning agility; ability to facilitate complex scientific, technical, value, and resourcing discussions.
• Ability to translate detailed scientific and technical insights into concise, impactful recommendations.
• Strong relationship‑building skills to become a trusted strategic partner to project teams and senior leaders.
• Ability to manage multiple projects, priorities, and fast‑paced decision cycles.

Closing Date for Applications - 10 February 2026 (EOD)

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service, or any basis prohibited under federal, state or local law.