Scientist​/Scientist II, Translational Medicine

Scientist/Scientist II, Translational Medicine

Boston;
Chicago;
San Francisco;
Seattle

About Jade Biosciences

Jade Biosciences is focused on developing innovative, best-in-class therapies to address critical unmet needs in autoimmune diseases. Our lead candidate, JADE
101, is designed to inhibit the cytokine APRIL (A Proliferation-Inducing Ligand) and is being developed for the treatment of immunoglobulin A nephropathy (IgAN), a chronic kidney disease that can impair kidney function over time. JADE
101 aims to reduce harmful IgA antibodies, lower proteinuria (a key marker of kidney damage), and preserve long‑term kidney function. A Phase 1 healthy‑volunteer study of JADE
101 is ongoing, with interim, biomarker‑rich data expected in the first half of 2026. Jade’s pipeline also includes a second development candidate, JADE
201, and an undisclosed antibody discovery program, JADE‑003, both currently in preclinical development.

Role Overview

The Research & Translational Medicine group at Jade is looking to add a Scientist/Scientist II to our team. The Scientist, Translational Medicine will develop, validate, and implement bioanalytical and biomarker assays to support Jade’s preclinical and clinical programs. This is a fully remote role and will require occasional travel.

Key Responsibilities

• Design, develop, and optimize bioanalytical and biomarker assays to assess drug potency, mechanism of action, and functional activity across preclinical and clinical programs.
• Select, qualify, and manage CRO partners for bioassay and biomarker development, transfer, and analysis, ensuring seamless execution, alignment on timelines, budgets, and quality expectations.
• Conduct detailed review and analysis of bioanalytical and biomarker data, ensuring rigorous scientific validity and compliance with regulatory standards.
• Collaborate with clinical and regulatory teams to draft, review, and finalize bioanalytical and biomarker sections of clinical protocols, investigator brochures, and regulatory submissions (e.g., IND, BLA), ensuring scientific accuracy and compliance with applicable guidelines.

Qualifications

• Scientist level:
  Ph.D. in a relevant scientific discipline with0‑3+ years of experience, M.S. with8+ years, or B.S. with 10+ years in bioanalytical or biomarker assay development. Scientist II level:
  Ph.D. in a relevant scientific discipline with3‑5+ years of experience, M.S. with
  10+ years, or B.S. with
  12+ years in bioanalytical or biomarker assay development.
• Proven experience managing sample analysis for global clinical trials and interfacing with regulatory authorities.
  
  Demonstrated ability to manage CROs, including contracting, study design, and technical oversight.
• Strong laboratory and project management skills, with expertise in critical thinking and scientific problem‑solving.
• Hands‑on experience with diverse assay platforms (e.g., flow cytometry, immunohistochemistry, ELISA, Luminex, MSD).
• Solid understanding of drug development processes and regulatory requirements.
• Excellent analytical, written, and oral communication skills, with strong interpersonal abilities.
• Highly motivated, detail‑oriented, and curious, with a creative approach to scientific challenges.
• Ability to travel for company meetings and scientific conferences as needed.

Position Location

This is a remote role; periodic travel to team and company events is required.

Salary Range

The anticipated salary range for candidates for this role at the Scientist level is $115,000 – $130,000 and at the Scientist II level $130,000 – $145,000. The final salary offered will depend on several factors, which may include, but is not limited to, relevant years of experience, educational background, and geography.

As part of the I‑9 verification of authorization to work in the United States, Jade Biosciences participates in E‑Verify. To learn more about E‑Verify, please review this poster.

Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.