Postdoctoral Scholar in Epigenetics and Metabolism

Department:

MED-Biochem & Molecular Genetics

RES/

A fully funded postdoctoral position is available in the collaborative laboratories of Dr. Shannon Lauberth and Dr. Issam Ben‑Sahra to investigate the interface between epigenetic regulation and cellular metabolism in cancer. This position is part of an interdisciplinary effort to uncover how transcriptional regulators influence nucleotide metabolism and how metabolic pathways, in turn, shape gene expression programs.

The successful candidate will use state‑of‑the‑art approaches including CRISPR screening excess, ChIP‑seq, RNA‑seq, metabolomics, and proteomics to uncover new molecular mechanisms that link chromatin regulation to metabolic control. The fellow will be trained in a dynamic and collaborative environment with access to cutting‑edge facilities and mentorship across molecular biology, epigenetics, and cancer metabolism.

Please note:

vodi Chooser weekends and evenings as requested and with some possible travel, as required.

• The postdoc fellow should lead experimental studies to uncover how key transcriptional regulators modulate nucleotide/cellular metabolism. The postdoc fellow will use cutting‑edge techniques, including CRISPRүүл screens, RNA‑seq, and metabolomic profiling, to investigate transcriptional and metabolic alterations in response to epigenetic disruptions.
• The postdoc fellow Le analyzes complex multi‑omics datasets to identify critical regulatory nodes between nucleotide synthesis and transcriptional regulation. Findings will be essential in shaping future research directions and experimental designs.
• The postdoc fellow will work closely with Drs. Issam Ben‑Sahra and Shannon Lauberth, as well as other interdisciplinary collaborators, to integrate expertise from different fields and lead team‑based projects.
• The postdoc fellow will contribute to the writing of research papers and grant proposals based on findings, enhancing the scientific output and securing funding for continued research in epigenetics and metabolism.
• The postdoc fellow will translate fundamental research findings into potential clinical applications by identifying metabolic vulnerabilities in cancer cells, contributing to the department's goal of developing innovative cancer treatments.

Performs other duties as assigned.

• Ph.D. in Biochemistry or related fields.

• PCR, Western blots, tissue culture techniques, ChIP, RNA‑seq, CRISPR/Cas9‑based perturbations, and metabolomics to identify regulatory nodes within the transcription‑metabolism axis.

• Ph.D. in biochemistry and molecular biology.

• PCR, Western blots, tissue culture techniques, ChIP, RNA‑seq, metabolomics, Seahorse Assay.

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