UNIV - Staff Scientist - Department of Neurosurgery

Overview

Job Description Summary We are seeking a highly motivated scientist interested in brain tumor immunology, a 1-year position at the Medical University of South Carolina. The scientist would be responsible in handling and processing of human brain tumor specimens including cryopreservation and tissue dissociation, extraction of nucleic acids, flow cytometry, microscopy imaging, single-cell RNA sequencing, and data analysis. The scientist would also be expected to assist with animal cancer model experiments including genetic tumor models, implantation of tumor cells, and eventually administration of therapies.

A background in molecular and cell biology, immunology, or neuroscience is desirable; however, otherwise motivated candidates interested in brain tumor research will be considered. Interest in clinical outcomes research of brain tumors is a strong plus.

Organization A staff scientist position at the Hollings Cancer Center (NCI-designated cancer center) of the Medical University of South Carolina is available in the newly forming Strickland Laboratory. Our primary aim is to understand the role of tumor heterogeneity and the tumor immune microenvironment as it permits immune tolerance in brain tumors. Our goal is to translate basic cancer immunology into targeted clinical immunotherapies.

We are particularly interested in glioblastoma and aggressive subtypes of meningioma. We focus on the interplay of immune cell proportions and communications within the tumor immune microenvironment as it correlates with tumor progression.

Entity Medical University of South Carolina (MUSC - Univ)

Worker Type Employee

Worker Sub-Type Research Grant

Cost Center CC000986 COM NSGY General CC

Pay Rate Type Salary

Pay Grade University-00

Pay Range 0.00 - 0.00 - 0.000

Scheduled Weekly Hours 40

Work Shift

Job Description

Job Duties:

• 30%:
  Assist with experimental data collections involving brain tumor human tissue processing. Collects samples (FFPE and in vivo), performs sample analyses, and extracts measurement data from experiments.
• 30%:
  Assist with study design and maintenance of study organization, including data entry and data storage through both document hard copies and electronically and to adapt new procedures, methods, or instrumentation relative to research procedures. This job duty includes organizing, writing, and renewing human (IRB) protocols, ensuring compliance with regulations, and maintaining communication with the institutional IRB.
• 15%:
  Oversee media preparation and equipment maintenance; quality control analysis reagents
• 10%:
  Supervise other personnel in the laboratory to coordinate research efforts for increased efficiency; participate in training of other lab members as needed
• 10%:
  Assist with ordering and procurement of supplies and equipment and with general maintenance of laboratory
• 5%:
  Other duties as assigned

MUSC Minimum Training And Experience
A Ph.D., M.D. or equivalent with two years postdoctorate experience.

Additional Knowledge, Skills, And Abilities Preferred

• Proficiency with immunology and/or tumor genetics investigations
• Familiarity with single cell RNA sequencing workflow and data processing
• Familiarity with immunohistochemistry and immunofluorescence
• Weekend, holiday, and evening work as required for experiments.

This position will work under direct supervision of the Strickland Brain Tumor Immunology PI, which will require numerous meetings on weekly and ad hoc bases. The staff scientist will primarily work in MUSC’s Hollings Cancer Center, with an expectation to attend meetings and other project-related activities as necessary.

Physical Requirements
:
The following descriptions are applicable to this section:
Continuous - 6-8 hours per shift;
Frequent - 2-6 hours per shift;
Infrequent - 0-2 hours per shift. Ability to perform job functions in an upright position; seated, walking, climbing stairs, working indoors, and other physical activities as described.

Additional New Requirements
:
Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work…