Accounts Payable Senior Manager

Headquartered in Carlsbad, California, Ionis is a company focused on RNA-targeted medicines with offices in Boston and Dublin. We are building a diverse team and fostering a culture of scientific excellence. If you’re passionate about impacting patients, apply to join Ionis.

• Oversee daily Accounts Payable operations to ensure timely invoice processing and payments
• Oversee daily Concur operations to ensure timely expense report audit and approvals
• Monitor workload, invoice and expense aging, and operational metrics to meet monthly close and service-level objectives
• Ensure compliance with internal controls, policies, and audit requirements
• Assist with internal Audit requirements to incorporate formal audit on the T&E side
• Act as the primary operational escalation point for AP and T&E issues
• Oversee AP and T&E shared mailboxes to ensure timely and professional responses
• Partner with cross-functional teams to resolve operational issues impacting AP and T&E

• Manage, coach, and develop AP team members, including workload assignment and prioritization
• Conduct regular one-on-ones, provide performance feedback, and complete year-end performance reviews
• Ensure consistent execution of processes and accountability across the team

• Lead the operational execution of system upgrades and enhancements (SAP, Coupa, Concur) with guidance and oversight from the AP Associate Director
• Ensure users are prepared for system changes, issues are resolved timely, and post-go-live operations are stabilized
• Maintain operational documentation and ensure adherence to established procedures

• Support internal and external audits by preparing documentation and responding to audit requests
• Support month-end close activities, including accruals, reconciliations, and variance analysis
• Lead the Form 1099 preparation and review

• Associate’s degree in Accounting, Finance, or related field (or equivalent experience)
• 8–10+ years of Accounts Payable experience, including people management
• Strong knowledge of AP and T&E operations, payments, reconciliations, and month-end close
• Hands-on experience with ERP and AP systems (SAP preferred; Coupa and Concur)
• Strong leadership, problem-solving, organizational, and communication skills
• Ability to operate independently, manage ambiguity, and prioritize competing operational demands

Please visit our website, , for more information about Ionis and to apply for this position; reference requisition # IONIS
003911. Ionis offers an excellent benefits package. Full Benefits Link:  The pay scale for this position is $80,727 to $115,000. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.