Senior Research Associate​/Assistant Director, ADQC

Summary

Seeking an experienced analytical chemist to join our Analytical Development & Quality Control (ADQC) group at the Sr. Research Associate, Senior Scientist or Assistant Director level (depending on experience). The ideal candidate will be familiar with a broad range of analytical chemistry techniques, possess a strong work ethic and strong technical background, demonstrate excellent oral and written communication skills, and have experience working in a GMP environment.

The successful candidate will be able to perform the following responsibilities with a high degree of independence and attention to detail.

• Manage the analytical activities for oligonucleotide therapeutic development projects
• Coordinate and execute testing of drug substance intermediate, drug substance, and drug product samples for release and stability studies
• Manage outsourced analytical activities at external contract labs
• Conduct analytical investigations
• Develop and optimize analytical methods
• Develop drug substance specifications ensuring efficient integration across Chemistry, Manufacturing, and Controls (CMC) and other relevant disciplines such as Clinical and Toxicology
• Design and execute method validation and method transfer protocols
• Author scientific reports and portions of the CMC section of regulatory filings
• Present at internal and cross-functional scientific meetings

• BS or MS with at least 5 years (Sr. Research Associate) or 8 years (Assistant Director) of industry experience in Analytical Chemistry or related discipline
• Ph.D. with at least 2 years (Sr. Scientist) or 8 years (Assistant Director) of industry experience in Analytical Chemistry or a related discipline
• Skilled in operating LC-MS, HPLC, and GC for the analysis of drug substance and drug product samples
• Good understanding of the drug development process
• Practical knowledge of GMP requirements, with hands-on GMP experience preferred
• Good understanding of ICH and FDA method validation guidelines, including phase-appropriate strategies
• Ability to problem solve, manage priorities and maintain aggressive timelines for multiple projects
• Ability to work productively and independently within a team or matrix environment
• Excellent written and verbal communication skills

Please visit our website, , for more information about Ionis and to apply for this position; reference requisition # IONIS
003870

Ionis offers an excellent benefits package. See Ionis Benefits for details.

Salary information: The pay scale for this position is $79,697 to $195,474. Sr. RA – Assistant Director (non-Ph.

D. track) is $79,697 to $129,130. Sr. Scientist – Assistant Director (Ph.D track) is $133,436 to $195,474.

Note: No phone calls, please. Principals only.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Equal Opportunity Employer. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.