Postdoctoral Fellow – variant to function map of lung cancer

Position: Postdoctoral Fellow – A variant to function map of lung cancer

Postdoctoral Fellow – A variant to function map of lung cancer

Apply for the Postdoctoral Fellow – A variant to function map of lung cancer role at Wellcome Sanger Institute in Cambridge, England, United Kingdom.

Overview

We are recruiting a Postdoctoral Fellow to join our Coelho Group for a 3‑year fixed‑term contract. Drug resistance limits the long‑term efficacy of cancer therapies. The aim of this project is to use CRISPR‑Cas9 based screening technologies, including base editing and prime editing, to systematically investigate the function of DNA variants commonly found in lung cancer. We will couple single‑cell transcriptomics with gene editing to deeply characterise cancer variant function  findings will enhance our understanding of cancer progression and drug resistance mechanisms and will inform new therapeutic strategies to overcome drug‑resistant disease.

What

You'll Be Doing

• Executing and analysing large‑scale screens and single‑cell sequencing experiments.
• Presenting findings internally and externally.
• Writing up publications.
• Supporting other lab members and facilitating training.
• Participating in the Postdoctoral Fellow community and training activities.

About You

You have completed a PhD or post‑doc in cancer biology, gene editing, genetics, or single‑cell sequencing. The role involves working in a laboratory using a variety of molecular biology techniques to generate high‑quality data for publication. You are required to possess analytical skills and coordinate with a multidisciplinary team. You have an interest in cancer biology, drug resistance, gene editing or single‑cell RNA sequencing, and proven experience using CRISPR technologies, screening, cell culture, flow cytometry, and molecular biology techniques such as PCR, cloning, lentivirus generation and next‑generation sequencing.

You will join a diverse and dynamic team environment.

Essential Skills

• PhD in a biological science or on track to be awarded your PhD within 6 months of starting the role.
• Proven track record of scientific productivity from datasets, publications, pre‑prints, reviews or resources.
• Experience in mammalian cell culture.
• Experience in performing single‑cell RNA‑seq or analysing single‑cell RNA‑seq datasets.
• Experience with molecular biology techniques, such as PCR and cloning.
• Experience in preparing libraries for next‑generation sequencing.
• Ability to keep good scientific records.
• Experience in bioinformatics and programming languages, such as Python or R.
• Experience in gene editing.
• Proven ability to work effectively within a team.
• Ability to work independently and organise workload.
• Demonstrable attention to detail.
• Demonstrated ability to adapt to regularly changing priorities and workloads.
• Ability to communicate ideas and results effectively to diverse stakeholders through discussion, talks, and publications.
• Ability to maintain supportive relationships, respecting diversity and cultural differences.
• Promote a positive, safe and efficient working environment.
• Take ownership of work, demonstrating pride, adaptability and accountability for achieving results.
• Uphold the highest ethical and scientific standards.

Other Information

For further information, please see the role profile.

Salary per annum

£38,000–£49,156 (dependent upon skills and experience).

Application Process

Please submit your CV and a cover letter detailing your research experience, interest in the focus area, future aspirations, and how you meet the criteria set out above.

Closing Date

27th January 2026

Hybrid Working at Wellcome Sanger

We recognise many benefits of hybrid working, including improved work‑life balance and focused time. The hybrid arrangement will vary by role and team. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity and Inclusion

We aim to attract, recruit, retain and develop talent from the widest possible talent pool. We have supportive staff networks for LGBTQ+, parents and carers, disability and race equity. We welcome all individuals without discrimination and are committed to creating an inclusive environment where everyone can thrive.

Our Benefits

We deliver a campus‑wide employee well‑being strategy and programme. We have a strong commitment to reducing work‑related stress and promoting good health. The Institute is a signatory of the International Technician Commitment initiative, empowering and recognising technicians across higher education and research.

Seniority Level

• Internship

Employment Type

• Full‑time

Job Function

• Research, Analyst, and Information Technology
• Industries:
  Research Services

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