Senior Associate Scientist

Senior Associate Scientist - Contract - Cambridge. MA

Are you a driven scientist ready to lead breakthrough research and accelerate drug discovery in a company at the forefront of pharmaceutical innovation?

Primary Responsibilities:

Proclinical is seeking a Senior Associate Scientist to support laboratory and process development activities for the chemical synthesis and downstream processing of oligonucleotide-based drug substances. This role involves hands-on lab work, analytical testing, and technical support for process optimization.

Skills & Requirements:

• Background in Chemistry or a related field; hands-on laboratory experience is preferred.
• Familiarity with analytical techniques such as pH measurement, osmolality, conductivity, HPLC, and LC-MS.
• Knowledge of oligonucleotide manufacturing processes, including phosphoramidite chemistry and chromatography, is advantageous.
• Strong commitment to maintaining high laboratory and scientific standards.
• Excellent organizational and documentation skills.
• Effective communication skills and a proactive, team-oriented mindset.

The Senior Associate Scientist's responsibilities will be:

• Conduct chemical synthesis of oligonucleotides at scales up to 11 mmol.
• Perform downstream processing, including preparative HPLC, ultrafiltration, annealing, concentration, and lyophilization.
• Carry out in-process analytical testing using techniques such as AX-HPLC, IPRP-HPLC, LC-MS, and UV-vis.
• Provide technical support for optimizing contract manufacturing processes.
• Maintain a safe, clean, and organized laboratory environment.
• Assist with routine laboratory and equipment maintenance.
• Ensure accurate record-keeping and adherence to excellent laboratory documentation practices.
• Collaborate effectively within a dynamic team environment to meet project timelines.

Compensation:

• $40 to $46 per hour

If you are having difficulty in applying or if you have any questions, please contact Jackie Cerchio at

If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.

Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.

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