Post-doctoral Fellow - Neuroprotection and Resilience

Job Title:  Post-doctoral Fellow - Neuroprotection and Resilience

Location: Cambridge, MA

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

Join our team in Sanofi neurology drug discovery research as a postdoctoral scientist and contribute to discovering life-changing therapies for Alzheimer's, Parkinson’s, and ALS. This 2-3 year position offers hands‑on experience in translational neuroscience, combining cutting‑edge neuronal physiology techniques with therapeutic development in a collaborative, cross‑functional environment.

The successful candidate will hold a PhD in neuroscience, neurodegeneration, neuroimmunology, or a related field, with demonstrated expertise in neuronal health assessment and primary neuronal or iPSC cell culture. Experience with gene therapy/silencing techniques and bioanalytical assays is highly valued. You will work at the intersection of discovery and drug development, with opportunities to publish in high-impact journals, present at scientific conferences, and build a strong foundation for your career in translational research.

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

• Develop and apply tools to assess neuronal health, including neuronal activity, neurite outgrowth, dendritic spine morphology, and synaptic density using high‑content imaging in primary or iPSC‑derived neurons.
• Validate in vivo mouse models of neurodegeneration to support proof‑of‑concept studies.
• Measure compound exposure and neuroinflammatory pathway changes in the CNS using ELISA and related bioanalytical approaches.
• Design and execute experiments, analyze data, and communicate findings at internal and external meetings and conferences.
• Publish research findings in high‑impact, peer‑reviewed scientific journals as first author and collaborative contributor.
• Collaborate effectively across cross‑functional teams within the Neuroscience Therapeutic Area, Research Platforms, and with external partners.

• Must have a PhD in neuroscience, neurodegeneration, neuroimmunology, or related discipline with a track record of peer-reviewed publications.
• Expertise in neuronal health assessment and synaptic density evaluation using high‑content imaging and bioanalytical assays (e.g., ELISA) in primary neuronal and/or iPSC‑derived cultures.
• Must be able to relocate to the office location and work 40hrs/week, Monday-Friday, for the full duration of the postdoc fellowship.
• Must be permanently authorized to work in the U.S. and not require sponsorship of an employment visa (e.g., H-1B or green card) at the time of application or in the future.

• Hands‑on experience with molecular biology techniques, including gene silencing or gene therapy approaches.
• Experience with in vivo rodent models of neurodegeneration.
• Experience with in vitro electrophysiological or calcium imaging recordings preferred.
• Highly organized and collaborative with strong analytical and communication skills.
• Ability to effectively engage with cross‑functional teams and communicate research progress to diverse scientific audiences.

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
• Exposure to…