Senior Research Associate, Oligonucleotide Chemistry

Position Title: Senior Research Associate, Oligonucleotide Chemistry

Reports To: Scientist II, Chemistry

Location: Cambridge, MA

Join the Adventure!

CAMP4 is seeking a passionate and innovative researcher to join our Chemistry team. The candidate will contribute to CAMP4’s in-house high throughput oligonucleotide synthesis and formulation capabilities. This is a laboratory-based role, and the successful candidate will bring experience of oligonucleotide synthesis, purification and analysis to advance our antisense oligonucleotide (ASO) pipeline. The successful candidate will be creative and flexible with enthusiasm for contributing in a high efficiency and fast-paced environment that is focused on urgently advancing drug candidates to help the unmet medical need of patients with CNS disorders.

This position will be based in our Cambridge, MA location.

• Independently execute high throughput oligonucleotide synthesis and characterization to meet project timelines.
• Perform oligonucleotide formulation and characterization, including assessment of concentration, purity, stability, and other critical quality attributes.
• Develop, conduct, and interpret analytical methods (e.g., HPLC, LC-MS, UV-Vis) to characterize and quantify oligonucleotides.
• Operate, troubleshoot and maintain laboratory instruments including automated oligonucleotide synthesizers, LC-MS, and HPLC.
• Collaborate with stakeholders across cross-functional teams to align on projects and meet timelines.
• Manage inventory of oligonucleotide sequences, reagents and critical supplies.
• Maintain thorough and timely records of experiments in accordance with company policies and procedures.

• Strong interpersonal, teamwork, communication, and organizational skills
• Ability to thrive in a dynamic, fast-paced, innovative environment
• Strong ability to manage timelines
• Maintain a high level of scientific integrity and lab safety
• Effectively engage with team, both willing to voice opinions and share ideas, while being receptive to feedback and other points of view.

• BS in chemistry or relevant life sciences with 5+ years or MS plus 2+ years of industry experience in oligonucleotide synthesis
• Demonstrated proficiency operating automated oligonucleotide synthesis equipment (Mermade, Dr. Oligo, etc.) is strongly desirable
• Competency with analytical techniques such as HPLC, LC-MS and UV-Vis
• Knowledge of oligonucleotide purification including ion-exchange and reverse-phase chromatography and experience with laboratory automation such as liquid handlers is a plus

At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $85,000.00 - $. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.

Our benefits include medical, dental, and vision insurance; life and disability coverage; paid parental leave; a 401(k) plan with company contribution;
Employee Stock Purchase Program, Trek Time (flexible time off); tuition assistance; and additional perks that support your well-being and professional growth.

CAMP4 is developing disease-modifying treatments for a broad range of genetic diseases where amplifying healthy protein may offer therapeutic benefits. Our approach amplifies mRNA by harnessing a fundamental mechanism of how genes are controlled. To amplify mRNA, our therapeutic ASO drug candidates target regulatory RNAs (regRNAs), which act locally on transcription factors and are the master regulators of gene expression. CAMP4’s proprietary RAPTM Platform enables the mapping of regRNAs and design of optimal chemistry to generate potent therapeutic candidates to address hundreds of genetic diseases across multiple tissues.

Learn more about us at  and follow us @CAMP4tx.