Principal Scientist, Protein Optimization

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Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Biotherapeutics R&D

Job Category: Scientific/Technology

All Job Posting Locations: Cambridge, Massachusetts, United States of America

Job Description:

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We are searching for the best talent for Principal Scientist, Protein Optimization in Cambridge, MA

Purpose: The Protein Engineering and In Vitro Discovery Team within Biologics Discovery is responsible for the design of lead biologic candidates across multiple therapeutic modalities. In this position, the Principal Scientist I will be an integral member of the Protein Optimization Engineering team that works on the cutting edge of protein science and technologies to deliver fit-for-purpose optimized protein sequences supporting the therapeutic pipeline.

As a member of the Protein Optimization team, you will be responsible for protein design and optimization with a strong focus on affinity, develop ability and other critical attributes using display technologies, structure and modeling-based design and other emerging computational or AI/ML methods. This role will also work closely with our in silico discovery colleagues, driving future advancements and technologies. This Principal Scientist is responsible for developing and implementing novel display-based binder selection/engineering/screening methods for rapid and validated selection of optimized antibody/protein variants.

This role offers an exciting opportunity to not only engage in the discovery and molecular engineering of biotherapeutics, but also develop new processes and technologies in collaboration with other functional groups. This Principal Scientist I will have the opportunity to lead project teams and interact seamlessly with world-class Therapeutic Area scientists.

You will be responsible for:

• Support protein optimization engineering efforts across the modality agnostic Therapeutics Discovery organization. Act as a point of accountability for engineering asks and manage project timelines independently.
• Develop and champion novel display-based platform development efforts aimed at fulfilling strategic long-term antibody design/optimization initiatives and validation.
• Lead/participate on project teams to advance discovery portfolio projects.
• Independently present/defend scientific findings in multi-functional project teams/initiatives.
• Independently plan, analyze and interpret experimental results and draft patent applications, manuscripts, protocols, SOPs, technical reports, etc.

Qualifications / Requirements:

• Education: A minimum of a MS Degree in in Molecular Biology, Biochemistry, Biotechnology, Biomedical Engineering, structural biology or related field is required. PhD is highly preferred.

Skills/Experience

Required:

• A minimum of 6 years of relevant experience is required.
• Demonstrated knowledge and experience in therapeutic development and ‘drug hunting’ mindset for large molecule therapeutics.
• In-depth knowledge and…