Senior Scientist, Process Chemistry

Senior Scientist, Process Chemistry page is loaded## Senior Scientist, Process Chemistry locations:
Cambridge, MAtime type:
Full time posted on:
Posted Todaytime left to apply:
End Date:
February 28, 2026 (30+ days left to apply) job requisition :
R2816965

Job Title:

Senior Scientist, Process Chemistry

Location:

Cambridge, MA
** About the Job
** The Commercial Process Development team, part of the CMC Synthetics Platform within the Sanofi R&D organization, is responsible for mid-to-late-stage process development for drug substances undergoing clinical development and for the chemical process to deliver the drug substance quality target profile. The Chemical Process Development team owns the eco-design strategy for the drug substance and, in collaboration with Analytical Sciences, Process Engineering and Clinical Manufacturing/External Technologies, defines the control strategy for the DS synthetic process.

We strongly believe that innovation in synthetic concepts and technologies, leveraging modeling, AI/ML and integration of biocatalysis are key drivers to transform drug substance process development to deliver drug substances in the most efficient, robust, economical, environmentally benign, and intrinsically safe way.

We are looking for a highly motivated and collaborative individual with expertise in synthetic organic chemistry, late-stage clinical development experience to join our Process Chemistry team at the Principal Scientist level. Under the direction of Process Chemistry R&D leadership, the primary responsibility of this role is to perform and oversee multi-step route evaluation and route development activities, with the aim of establishing commercial drug substance manufacturing processes through management and execution of internal and outsourced laboratory activities.

This role may oversee the activities of one or more collaborators and be responsible for their professional development.
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* Main Responsibilities:

*** Contribute to the design of novel and efficient synthetic pathways for drug substances undergoing clinical development
* Conduct and oversee route scouting in laboratory to demonstrate synthetic viability
* Use all imaginable chemistry tools and methods to develop and optimize commercial process for selected drug substance route (photochemistry, biocatalysis, flow chemistry, electrochemistry, on-line analysis/PAT, high-throughput experimentation, structural analysis, computational chemistry, etc.)
* Design, plan and execute experimental plans to optimize reaction, purification and isolation unit operations, guided by technical risk assessments, to deliver safe, efficient, robust and scalable drug substance manufacturing processes that perform reliably at intended scale in batch or continuous format
* Collaborate within project teams by working closely with analytical chemists, process engineers, pilot plant experts and project managers within the CMC Synthetics organization
* Communicate scientific results in a clear, concise, and accurate manner via electronic laboratory notebook documentation, development reports, project discussions and presentations
* Provide concise technical presentations to communicate work to project teams, cross functional teams and management.  Document all work on projects and continuous improvements in eLNB experiments and summarize in technical reports
* Establish/extend external network by providing representation and leadership on academic, industrial, or government sponsored collaborations.
* Champion continuous improvements through pursuit of scientific and technical innovations, workflow optimizations, and incorporation of digital tools
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* About You:

*** Ph.D. in organic or synthetic chemistry.
* Knowledge in at least one of the following areas: advanced analytics, flow chemistry, high throughput experimentation.
* Experience in chemocatalysis or biocatalysis including characterization of catalytic processes and/or mechanistic analysis.
* Computational capabilities and basic coding skills.
* Strong publication record in peer-reviewed journals.
* Excellent written and verbal communication skills.
* Ability to operate with flexibility in a dynamic environment…