Associate Director​/Director, Antisense Oligonucleotide Chemistry

Position Title: Associate Director/Director, Antisense Oligonucleotide Chemistry

Reports To: Chief Scientific Officer

Location: Cambridge, MA

Join the Adventure!

We are seeking an experienced and highly motivated Associate Director of Antisense Oligonucleotide (ASO) Chemistry to lead a small team of scientists focused on discovery-stage oligonucleotide synthesis and formulation. This individual will lead a small team of chemists, provide both scientific and strategic guidance, and help shape the evolution of our ASO platform capabilities. The ideal candidate is a collaborative, adaptable oligonucleotide chemistry leader with deep technical expertise.

This is an onsite position.

• Leadership & Team Management
  • Lead, mentor, and develop a team of ~3 scientists engaged in ASO synthesis, purification, and formulation.
  • Set clear priorities, manage workflows, and ensure high‑quality, timely scientific execution.
  • Foster a collaborative, inclusive, and growth‑oriented team culture.
• Scientific & Technical Responsibilities
  • Oversee oligonucleotide synthesis, including small and medium scale synthesis, and external vendor management.
  • Drive method development and process optimization for high‑throughput synthesis, purification, and formulation.
  • Maintain strong technical rigor across all experimental work; provide troubleshooting, guidance, and hands‑on laboratory support as needed.
  • Evaluate new technologies, methodologies, and platforms to enhance ASO chemistry capabilities.
• Cross‑Functional Collaboration
  • Partner closely with discovery and platform teams to drive discovery projects and innovation.
  • Communicate complex chemistry concepts clearly to diverse audiences, ensuring alignment between chemistry strategy and program goals.
  • Contribute to project planning, timelines, risk assessments, and decision‑making.
• Strategic Contributions
  • Provide scientific and strategic insights into ASO program direction, platform development, and long‑term capability planning.
  • Help define and drive improvements in ASO design workflows, synthesis efficiency, and quality standards.
• Operational Excellence
  • Ensure accurate documentation, data organization, and reporting across projects and team activities.
  • Contribute to internal presentations, external collaborations, and regulatory‑relevant documentation as needed.

• Ph.D. in Chemistry, Chemical Biology, or a related field with 8+ years of relevant experience.
• Proven expertise in antisense oligonucleotide chemistry or related nucleic acid modalities.
• Demonstrated experience leading and developing scientific teams.
• Strong understanding of ASO synthesis technologies, purification approaches, and formulation principles.
• Excellent communication, writing, and organizational skills.
• Demonstrated success working in fast‑paced, matrixed environments with shifting priorities.
• Ability and willingness to perform hands‑on laboratory work.
• Strong problem‑solving skills, scientific creativity, and a collaborative mindset.

• Highly adaptable and energized by rapidly evolving science.
• Comfortable balancing tactical execution with strategic thinking.
• Strong interpersonal skills and a track record of effective cross‑functional partnership.
• Motivated by mentoring others and building strong team culture.

At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $ - $. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.

Our benefits include medical, dental, and vision insurance; life and disability coverage; paid parental leave; a 401(k) plan with company contribution;
Employee Stock Purchase Program, Trek Time (flexible time off); tuition assistance; and additional perks that support your well‑being and professional growth.

CAMP4 is developing disease‑modifying treatments for a broad range of genetic diseases where amplifying healthy protein may offer therapeutic benefits. Our approach amplifies mRNA by harnessing a fundamental mechanism of how genes are controlled. To amplify mRNA, our therapeutic ASO drug candidates target regulatory RNAs (regRNAs), which act locally on transcription factors and are the master regulators of gene expression. CAMP4’s proprietary RAPTM Platform enables the mapping of regRNAs and design of optimal chemistry to generate potent therapeutic candidates to address hundreds of genetic diseases across multiple tissues.

Learn more about us at  and follow us @CAMP4tx.