Oligonucleotide Scientist , Process Development

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas
12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases.

At Editas Medicine, we’re a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor!

The Process Development team within the Technical Operations Group is seeking a highly motivated scientist to support the development and production of critical RNA-based gene editing components. The successful candidate will contribute to advancing in vivo LNP programs from preclinical through to clinical stages by producing guide-RNA (gRNA) materials at small scale to support research and development efforts.

This role requires hands-on experience across both upstream and downstream aspects of the gRNA manufacturing process, as well as proficiency in analytical testing of gRNA intermediates and final products. A strong background in oligonucleotide synthesis, deprotection, and purification is a must. Additionally, the candidate will serve as a subject matter expert (SME) in interactions with external suppliers (both research-grade and GMP) and collaborate closely with the research team on molecule design and optimization.

As the oligonucleotide scientist, you will:

• Manage external vendor activities to supply gRNA (research and GMP grades)
• Provide subject expertise internally and externally regarding gRNA design, quality characteristics, and production processes.
• Prepare oligonucleotide synthesis reagents and synthesize, process, and purify guide-RNA using automated instruments as well as hands-on techniques.
• Analyze final products and intermediates, interpret data, and make independent process decisions.
• Desalt, concentrate, and lyophilize final gRNA material using scale-appropriate instrumentation or techniques.
• Coordinate with members of other teams and manage material requirements, priorities, and timelines.
• Present data and development strategies within the group and to cross-functional departments.
• Adapt as needed to meet the needs of the most critical project(s).
• Assist with the coordination of instrument preventative maintenance and repairs.
• Maintain an electronic laboratory notebook and miscellaneous documentation.
• Maintain reagent inventory.

To thrive in this role, you’ll need:

• PhD in Chemical Engineering, Chemistry, Pharmacy, Biochemistry or related discipline with 3 years relevant industry experience, Master’s degree with 6+ years of relevant industry experience, or Bachelor’s degree 8+ years of relevant industry experience.
• In-depth knowledge of DNA, RNA, and oligonucleotide design, production methods, impurities, and analytics.
• Experience with oligonucleotide synthesizers, specifically Bio Automation/LGC Mer Made platforms.
• Experience with preparative-scale HPLC purification instruments.
• Experience with molecular-weight-cutoff (MWCO) desalting methods and/or UF/TFF instrumentation a plus.
• Experience with nucleic acid analytics, including HPLC, LCMS, and UV spectroscopy.
• Experience with aseptic / RNase-free handling and operation.
• Excellent time and project management.
• Ability to work effectively in a cross-functional team environment.
• Excellent oral and written communication skills.
• Technical troubleshooting and organizational skills.
• Proficient with Microsoft Office programs.
• Prior experience managing external CRO and CDMO vendors is a plus
• Experience in high throughput processing…