Senior​/Principal Scientist, Medicinal Chemistry

Senior/Principal Scientist, Medicinal Chemistry

Cambridge, MA

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

Company Description

Expedition Medicines is a privately held, early‑stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design. Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact.

We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

About the role:

We are seeking a Senior / Principal Scientist level medicinal chemist to join our chemistry team at Expedition Medicines. This position will be responsible for the medicinal chemistry strategy and delivery on one or more projects. A candidate with experience collaborating with a machine learning team to deliver against project goals is a plus.

Candidate responsibilities:

• Design and deliver medicinal chemistry strategy on project(s).
• Optimize small molecules through analysis of biochemical, biological, and ADME assay data.
• Manage chemistry CROs for timely delivery of synthetic efforts.
• Collaborate with cross‑functional teams for project needs in high‑paced data‑driven environment.
• Collaborate with machine learning team for delivery against medicinal chemistry strategy.
• Contribute to patent applications and scientific publications.

Qualifications
:

• PhD in synthetic organic or medicinal chemistry with at least 5 years’ drug discovery experience in pharmaceutical industry or BS/BA in chemistry with at least 10 years’ experience in pharmaceutical industry.
• Strong modern synthetic background preferred with knowledge of state‑of‑the‑art organic chemistry methodologies.
• Experience managing external chemistry CROs.
• Experience collaborating with machine learning teams preferred.
• Experience with both traditional small molecules and beyond‑rule‑of‑5 therapeutic modalities is a plus.
• Strong communication and interpersonal skills.

LOCATION:Cambridge, MA

ABOUT FLAGSHIP PIONEERING

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer
. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification
. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies
:
Flagship Pioneering and its…