Scientist​/Senior Scientist, Immunology

Typewriter Therapeutics is a genome engineering and next-generation gene therapy company. Through repurposing a class of genetic elements from various natural genomes, Typewriter Therapeutics aims to develop an all-RNA-mediated gene writing platform via nonviral delivery to address unmet therapeutic needs.

We are seeking a highly motivated, collaborative and resourceful scientist/senior scientist with extensive experience in CAR-T and T cell biology. The successful candidate will be a key member of the immunology team, to enable both early-stage discovery research efforts as well as the development of drug product formulations for our preclinical animal study candidates. This is a hands-on, on-site laboratory role.

This individual will be responsible for the design and optimization of our CAR-T in vitro assays and will interface with cross-functional teams including delivery, analytical, pharmacology, and manufacturing to advance platform initiatives and pipeline programs. The ideal candidate will have a proven track record of developing CAR-T in vitro assays (including co-cultures, cytokine release assays, immunophenotyping, CAR-T cell expansion, flow cytometry, ex-vivo processing, etc).

Previous experience with LNPs, pharmacology, CAR-T design, and gene editing is a plus. The candidate is expected to be a strong collaborator who enjoys scientific discovery, has a passion for working on cutting-edge technology, and can communicate effectively in a fast-paced, dynamic, and interdisciplinary environment.

• Design, implement, and execute T cell in vitro assays including (but not limited to) CAR-T co-cultures, cytokine release assays, immunophenotyping, CAR-T cell expansion, flow cytometry, and ex-vivo processing
• Collaborate with external CROs
• Maintain meticulous documentation of all experimental data, procedures, and protocols
• Review and analyze data and be able to present and explain across the functional teams
• Collaborate with a team of scientists to creatively solve problems and drive innovation
• Maintain high standards for scientific integrity and accountability

• PhD in immunology, cell biology, pharmacology, or related discipline, MS with at least 4 years of relevant industry experience, BS with at least 7 years of relevant industry experience
• Hands on experience with the following: CAR-T, flow cytometry, primary cell (immune cells) and cell line culturing, co-cultures, ex-vivo processing, T cell immunophenotyping, cytokine release assays, qPCR, electroporation
• Able to conduct self-directed research and thrive in a dynamic and fast-paced entrepreneurial setting with a diverse team of coworkers
• Exceptional problem-solving skills, outstanding interpersonal skills, creativity, enthusiasm, and reliability
• Strong organizational skills, attention to detail, and meticulous data documentation
• Ability to prioritize multiple tasks while maintaining accuracy
• Effective verbal and written communication skills for cross-functional collaboration
• Flexibility to adapt to evolving project priorities in a dynamic environment
• Scientifically curious, paired with a strong work ethic and grit
• Open-minded, respectful of others, and a strong proponent of an inclusive culture
• Embraces the lean start-up mentality and is willing to wear multiple hats

• Mid-Senior level

• Full-time

• Research, Analyst, and Information Technology