Senior Scientist, Discovery BioSciences Oncology

R1598206 :
Senior Scientist, Discovery Bio Sciences Oncology

Company: Bristol-Myers Squibb

Req Number: R1598206

Location: Cambridge Crossing-MA

We are seeking a highly motivated, experienced and talented Senior Scientist to join our Discovery Biosciences team. This individual will play a key role in advancing our oncology drug discovery programs, with a focus on cancer immunology and next-generation biotherapeutic target identification, validation, mechanism of action and optimization studies.

• Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development
• Strong biology skills with experience using a wide range of cellular and molecular biology techniques, 2D and 3D cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning, western blotting, immunoprecipitation, ELISA, and MSD
• Experience with in vivo oncology and/or immunology models. Animal handling is not a requirement, but the candidate should understand the strengths and weaknesses of commonly used cancer immunology models, and have experience with downstream tissue processing (dissociation, flow cytometry, IHC)
• Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown, nucleofection, and CRISPR-mediated genome editing)
• Design, optimize, and troubleshoot complex cell-based and in vivo assays to evaluate therapeutic candidates and understand cancer signaling pathways
• Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals
• Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings
• Contribute to the preparation of technical reports, publications, and presentations

• Bachelor's Degree
• 7+ years of academic and / or industry experience

Or

• Master's Degree
• 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
• 2+ years of academic and / or industry experience

• PhD and 2+ years of academic and / or industry experience preferred
• Extensive experience in oncology research, with background in cancer immunology and/or biotherapeutics (e.g. ADCs, multi-specifics, and TCEs) is strongly preferred
• Proven track record with designing and developing a variety of molecular biology and cellular assays
• Hands on experience with functional genomics, CRISPR screens, high content imaging, flow cytometry, RNA-seq and proteomics is highly desirable
• Proficiency in data analysis software (e.g., Graph Pad Prism, Flow Jo) and familiarity with bioinformatics tools
• Familiarity with querying large-scale oncology datasets (Dep Map, cBioPortal, TCGA) to generate and test hypotheses
• Effective troubleshooting skills when optimizing assays and when developing innovative methodologies

Cambridge Crossing: $137,570 - $166,706

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final, individual compensation will be decided based on demonstrated experience.

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

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If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway.

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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Provided by BMS Recruitment Team