Director, Operations - KCO, Regev and Xavier Lab

About the Broad Institute

The Broad Institute brings together a collaborative community of researchers from MIT, Harvard, and affiliated hospitals with the mission of advancing the understanding and treatment of human disease. apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. Through our partnerships with MIT, Harvard, and the Harvard teaching hospitals, we've become a worldwide hub of cutting-edge biomedical science.

The Xavier Lab combines cutting-edge technologies with molecular biology, immunology, genomics, and systems biology. Our research focuses on translating human genetics to functional biology; generating systems-wide maps within the gut that capture immune features and metabolic states at single-cell resolution; determining the influences of the gut microbiome on health and disease using human cohorts and computational models; and, identifying and placing new cellular receptors within pathway biology and leverage chemical biology to test therapeutic hypotheses and inform drug discovery program.

We are seeking a highly motivated individual to join our team of talented professionals and researchers in a highly collaborative research environment. Come join a team excited to learn and make an impact on human health!

The Director of Operations serves as a trusted strategic partner to senior leadership, overseeing operational performance, coordinating lab-wide initiatives, and ensuring that administrative and strategic priorities advance efficiently. This individual is responsible for driving execution, improving cross-functional workflows, supporting decision-making, and fostering a culture of collaboration and continuous improvement. This role requires exceptional organizational leadership, scientific or research-environment fluency, and the ability to operate with sound judgment in a complex, fast-paced, research-focused institution.

• Serve as a strategic advisor to senior leadership, helping shape priorities, organizational plans, and long-range initiatives.
• Oversee daily operational activities across functional areas (administration, sponsored research, finance, legal and HR).
• Partner with scientific and administrative leaders to identify operational challenges and implement solutions.
• Partner with scientific and operational leadership to ensure administrative functions proactively support evolving research priorities.
• Drive continuous improvement efforts, promoting efficiency, transparency, and effective communication across teams.
• Oversee budgeting, forecasting, financial reporting, and financial planning across the lab.
• Ensure strong internal controls, compliance with reporting requirements, and responsible stewardship of institutional resources.
• Support strategic resource allocation and long-range financial planning in collaboration with senior leadership.
• Support annual budgeting and resource planning processes in partnership with finance and program leadership.
• Monitor budgets, staffing allocations, space planning, and operational expenditures to ensure alignment with strategic priorities.

• Bachelor's degree; advanced degree preferred (MBA, MPH, MPA, MS/PhD in a scientific field, or related discipline).
• At least 10 years of progressively responsible experience in operations, strategic planning, project management, or program leadership, preferably within a research, academic, biomedical, or nonprofit environment.
• Demonstrated ability to lead complex, cross-functional initiatives and manage multiple high-priority projects simultaneously.
• Exceptional communication, facilitation, and interpersonal skills with the ability to work effectively at all organizational levels.
• Understanding of budgeting, research operations, grant management and laboratory operations.
• Strong analytical, organizational, and systems-thinking capabilities.
• Prior experience serving as a comparable executive-level operations leader.
• Proven track record of team leadership and organizational development.

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.

At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other…