Principal Scientist, Spatial Omics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Biological Research

Job Category: Scientific/Technology

All Job Posting Locations: Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science‑based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

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We are searching for the best talent for a Principal Scientist, Spatial Omics located in Cambridge, MA or Spring House, PA.

Purpose: The ideal candidate will lead the development, validation, and deployment of cutting‑edge spatial and molecular profiling capabilities to advance therapeutic discovery across neuroscience, oncology, and immunology, with deep expertise in at least one of these areas strongly preferred. This principal scientific role is both strategic and hands‑on, responsible for designing, optimizing, and validating molecular and spatial assays to ensure robustness, reproducibility, and biological interpretability.

The principal scientist will drive end‑to‑end workflows spanning tissue processing, immunohistochemistry, in situ hybridization, microscopy, and slide‑based imaging. They will lead the development of novel molecular assays, establish and optimize lab infrastructure, and guide technical execution across multiple platforms. Additional responsibilities include building data generation pipelines, troubleshooting complex experiments, and managing CROs and external technology partners to accelerate capability development. The role will also provide opportunities for validating observations in relevant in vitro and ex vivo model systems.

Ideal candidates bring deep experience in spatial genomics, particularly in a disease context, along with strong experimental design skills and the ability to rapidly deploy assays across cell and tissue samples. Preferred experience also includes basic computational literacy for mapping data flows, as well as familiarity with massively parallel reporter assays, library design, or cell engineering.

You will be responsible for:

• Leading the development, optimization, and validation of spatial genomics and molecular profiling assays to support neuroscience, oncology, and immunology programs.
• Designing and executing experimental workflows involving tissue processing, immunohistochemistry, in situ hybridization, microscopy, high‑resolution slide imaging and sequencing. Experience with Bruker Cos Mx and 10x Genomics Visium is highly preferred and will be required for this role.
• Establishing and refining new molecular assays, including troubleshooting, workflow development, and technical feasibility assessments.
• Building and scaling laboratory infrastructure, including lab setup, instrumentation planning, and operational readiness.
• Managing CROs and external partners, ensuring high‑quality data generation, timeline alignment, and technical deliverables.
• Collaborating closely with therapeutic area teams to translate multiomics and spatial readouts into actionable biological insights.
• Contributin…