Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome.

We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex‑vivo models of cancer biology and immuno‑oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.

We are optimally positioned to complement the world‑class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world‑class science, innovation, and business opportunities.

• Function as Pharmacology lead as well as provide support for T cell engager drug discovery programs. Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to complex projects.

• Demonstrate critical thinking to address project challenges and independently drive the program forward with solution‑oriented mindset.

• Characterize drug candidates in vivo as part of the lead selection process, utilizing strong foundational knowledge of building PK, PD, BioD and efficacy relationship in vivo and employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND.

• Identify and develop state‑of‑the‑art in vivo models, experimental protocols and relevant assays. Work with cross‑functional teams participate in development and implementation of program strategy, including integrating in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings.

• Design, independently execute and deliver experiments with comprehensive high‑quality data sets to drive decision making. Interpret results of complex experiments. Use relevant information, technology and resources, contributing to complex team problem resolution and goals. Proactively foster relationships across disciplines to facilitate decision making process.

• Participates in the decision‑making process for completion of team goals and communicates program strategy and timelines to Project teams. Prepare and present comprehensive technical or project updates in team meetings and other forums.

• Leads initiatives related to development of new approaches / technologies within T-Cell engager strategy. Encourages use of…