Senior Director, Business

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Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow‑on product candidate, OP-3136, is a potent KAT6 inhibitor with best‑in‑class potential. Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another.

At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for our patients, for your career, for what’s beyond.

As the Senior Director of Business Applications reporting to the Vice President, Information Technology, you are a seasoned and visionary leader who will oversee and optimize all General & Administrative (G&A) business systems. You will lead a high‑impact team in enhancing, hardening, and scaling enterprise systems to support Olema’s transition toward commercialization and sustained growth. This is a unique opportunity to make a meaningful impact at a dynamic biotech company during a pivotal phase in its development.

This role is based in either our San Francisco or Boston office and will require 10% travel.

• Own the strategic roadmap, budget, and day‑to‑day management of G&A business systems including Net Suite, Prendio, Agiloft, Bamboo
  
  HR, Greenhouse, and Culture Amp
• Harden existing systems to prepare for commercialization and ensure enterprise scalability, audit readiness, and compliance with SOX (404A & 404B) requirements
• Partner with Finance, HR, Legal, Procurement, Talent, Facilities and IT teams to understand evolving business requirements and deliver efficient, scalable solutions
• Ensure successful adoption of new technologies and enhancements through structured change management practices, including communication, training, and stakeholder alignment
• Evaluate and implement AI‑driven tools and automation platforms, and workflow optimization solutions – such as Workato or similar iPaaS technologies – to improve business performance and operational efficiency
• Drive continuous improvement and digital transformation efforts by identifying opportunities for process redesign, automation and integration across systems
• Ensure application governance, data integrity, system security, and adherence to internal controls and SOX processes
• Lead system and vendor evaluations, platform assessments, and RFP processes to achieve the optimal technical fit and value for the organization
• Manage vendor relationships and contract negotiations for SaaS platforms and service providers
• Provide oversight and partnership with R&D teams (~10–15% of your time) to support scientific applications, data workflows, and system integrations that enable research innovation
• Mentor and grow a high‑performing Business Applications team aligned with Olema’s culture and mission

Knowledge:

• Bachelor’s degree in information systems, computer science, or related discipline; advanced degree preferred
• Strong knowledge of AI technologies, data management, and automation tools to drive digital transformation
• Demonstrated leadership in managing cross‑functional teams and complex system implementations
• Proven success scaling and hardening systems in preparation for commercialization
• Demonstrated ability to translate business requirements into technical solutions and architect scalable, future‑ready systems

Experience:

• Minimum of 10+ years of experience managing enterprise applications, with a strong background in G&A systems within the biotech or pharmaceutical industry
• Minimum of 5+ years of experience building, leading, managing, developing and mentoring direct reports
• Hands‑on experience with Net Suite is a must. Prendio, Agiloft, Bamboo
  
  HR, Greenhouse, Culture Amp, Workato or similar tools highly preferred
• Track record of process…